Central Diagnostic Laboratory

Research output

Research output per year 1987 2006 2016 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 512 Article
• 60 Review article
• 44 Doctoral thesis 1 (Research UU / Graduation UU)
• 33 Comment/Letter to the editor
• 74 More
  • 25 Meeting Abstract
  • 13 Editorial
  • 10 Chapter
  • 10 Preprint
  • 9 Letter
  • 2 Short survey
  • 1 Book
  • 1 Conference contribution
  • 1 Foreword/postscript
  • 1 Literature review
  • 1 Patent

Research output per year

Research output per year

Search results

• 2024

  A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example

  Wesseling, M., Diez-Benavente, E., Mokry, M., den Ruijter, H. M. & Pasterkamp, G., Mar 2024, In: Vascular Pharmacology. 154, p. 1-5 5 p., 107286.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cell Plasticity 100%
  • Physiological Adaptation 97%
  • Critical Pathways 87%
  • Atherosclerosis 60%
  • Biological Phenomena 14%
  1 Downloads (Pure)

• Airway and Blood Monocyte Transcriptomic Profiling Reveals an Antiviral Phenotype in Infants With Severe Respiratory Syncytial Virus Infection

  15 Mar 2024, In: The Journal of infectious diseases. 229, Supplement_1, p. S100-S111 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Respiratory Syncytial Virus Infections 100%
  • Antiviral Agents 66%
  • Monocytes 63%
  • Respiratory Syncytial Viruses 56%
  • Phenotype 46%

• A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles

  Francia, V., Zhang, Y., Cheng, M. H. Y., Schiffelers, R. M., Witzigmann, D. & Cullis, P. R., 12 Mar 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 11, e2307803120.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nanoparticles 100%
  • Lipids 73%
  • ferric oxide 21%
  • Nucleic Acids 17%
  • RNAi Therapeutics 14%

• A novel composition of endogenous metabolic modulators improves red blood cell properties in sickle cell disease

  van Dijk, M. J., Traets, M. J. M., van Oirschot, B. A., Ruiter, T. J. J., de Wilde, J. R. A., Bos, J., van Solinge, W. W., Koziel, M. J., Jans, J. J. M., Wani, R., van Beers, E. J., van Wijk, R. & Rab, M. A. E., Feb 2024, In: EJHaem. 5, 1, p. 21-32 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Sickle Cell Anemia 100%
  • Erythrocytes 71%
  • Amino Acids 16%
  • Laminin 12%
  • Hemolysis 11%

• Assessment of feto-placental oxygenation and perfusion in a rat model of placental insufficiency using T2* mapping and 3D dynamic contrast-enhanced MRI

  Al Darwish, F. M., Coolen, B. F., van Kammen, C. M., Alles, L. K., de Vos, J., Schiffelers, R. M., Lely, T. A., Strijkers, G. J. & Terstappen, F., Jun 2024, In: Placenta. 151, p. 19-25 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Placental Insufficiency 100%
  • Perfusion 52%
  • Pressure 18%
  • Pre-Eclampsia 11%
  • Placenta 10%

• Association between BMD and coronary artery calcification: an observational and Mendelian randomization study

  Lu, H., Lary, C. W., Hodonsky, C. J., Peyser, P. A., Bos, D., van der Laan, S. W., Miller, C. L., Rivadeneira, F., Kiel, D. P., Kavousi, M. & Medina-Gomez, C., Apr 2024, In: Journal of Bone and Mineral Research. 39, 4, p. 443-452 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Random Allocation 100%
  • Bone Density 92%
  • Coronary Vessels 83%
  • Linear Models 14%
  • Vascular Calcification 12%

• Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans

  Benavente, E. D., Hartman, R. J. G., Sakkers, T. R., Wesseling, M., Sloots, Y., Slenders, L., Boltjes, A., Mol, B. M., de Borst, G. J., de Kleijn, D. P. V., Prange, K. H. M., de Winther, M. P. J., Kuiper, J., Civelek, M., van der Laan, S. W., Horvath, S., Onland-Moret, C., Mokry, M., Pasterkamp, G. & den Ruijter, H. M., Jun 2024, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 44, 6, p. 1419-1431 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Atherosclerotic Plaques 100%
  • Acceleration 93%
  • Epigenomics 83%
  • Atherosclerosis 12%
  • Endothelial Cells 11%
  1 Downloads (Pure)

• Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro

  van Straten, D., Sork, H., van de Schepop, L., Frunt, R., Ezzat, K. & Schiffelers, R. M., Sept 2024, In: Journal of Controlled Release. 373, p. 481-492 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration

  Labonia, M. C. I., Estapé Senti, M., van der Kraak, P. H., Brans, M. A. D., Dokter, I., Streef, T. J., Smits, A. M., Deshantri, A. K., de Jager, S. C. A., Schiffelers, R. M., Sluijter, J. P. G. & Vader, P., May 2024, In: Journal of controlled release : official journal of the Controlled Release Society. 369, p. 734-745 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Messenger RNA 100%
  • Nanoparticles 80%
  • Lipid 62%
  • Lipids 59%
  • Nanoparticle 45%
  1 Downloads (Pure)

• CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders

  Picavet, L. W., Samat, A. A. K., Calis, J., Nijhuis, L., Scholman, R., Mokry, M., Tough, D. F., Prinjha, R. K., Vastert, S. J. & van Loosdregt, J., 18 Jun 2024, In: Biomedicines. 12, 6, 14 p., 1344.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • CREB-Binding Protein 100%
  • Disorder 58%
  • T-Lymphocytes 42%
  • Juvenile Arthritis 32%
  • Protein 28%

• CD163 + Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma.

  Mori, M., Sakamoto, A., Kawakami, R., Guo, L., Slenders, L., Mosquera, J. V., Ghosh, S. K. B., Wesseling, M., Shiraki, T., Bellissard, A., Shah, P., Weinkauf, C. C., Konishi, T., Sato, Y., Cornelissen, A., Kawai, K., Jinnouchi, H., Xu, W., Vozenilek, A. E., Williams, D., & 15 othersTanaka, T., Sekimoto, T., Kelly, M. C., Fernandez, R., Grogan, A., Coslet, A. J., Fedotova, A., Kurse, A., Mokry, M., Romero, M. E., Kolodgie, F. D., Pasterkamp, G., Miller, C. L., Virmani, R. & Finn, A. V., 5 Jul 2024, In: Circulation research. 135, 2, p. e4-e23

  Research output: Contribution to journal › Article › Academic › peer-review

  • Atherosclerotic Plaques 100%
  • Macrophages 67%
  • Endothelial Cells 26%
  • Apolipoproteins E 25%
  • Hemorrhage 23%

• Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior

  Jansen, S. A., Cutilli, A., de Koning, C., van Hoesel, M., Frederiks, C. L., Saiz Sierra, L., Nierkens, S., Mokry, M., Nieuwenhuis, E. E. S., Hanash, A. M., Mocholi, E., Coffer, P. J. & Lindemans, C. A., 21 Jun 2024, In: iScience. 27, 6, p. 1-19 19 p., 110072.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Galectins 100%
  • Organoids 94%
  • T-Lymphocytes 44%
  • Drug Therapy 42%
  • Cell Proliferation 28%

• Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo

  Walther, J., Porenta, D., Wilbie, D., Seinen, C., Benne, N., Yang, Q., de Jong, O. G., Lei, Z. & Mastrobattista, E., Mar 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 196, 11 p., 114207.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Ribonucleoproteins 100%
  • Gene Editing 99%
  • Clustered Regularly Interspaced Short Palindromic Repeats 92%
  • Nanoparticles 71%
  • Lipid 55%

• Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells

  Hernández-López, P., van Diest, E., Brazda, P., Heijhuurs, S., Meringa, A., Hoorens van Heyningen, L., Riillo, C., Schwenzel, C., Zintchenko, M., Johanna, I., Nicolasen, M. J. T., Cleven, A., Kluiver, T. A., Millen, R., Zheng, J., Karaiskaki, F., Straetemans, T., Clevers, H., de Bree, R., Stunnenberg, H. G., & 6 othersPeng, W. C., Roodhart, J., Minguet, S., Sebestyén, Z., Beringer, D. X. & Kuball, J., Jan 2024, In: Nature immunology. 25, 1, p. 88-101 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Metabolome 100%
  • Antigens 56%
  • T-Lymphocytes 54%
  • T-Cell Antigen Receptor 45%
  • Neoplasms 28%

• Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells

  Wang, J., Liu, S., Meng, X., Zhao, X., Wang, T., Lei, Z., Lehmann, H. I., Li, G., Alcaide, P., Bei, Y. & Xiao, J., Mar 2024, In: Circulation research. 134, 5, p. 550-568 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Cardiotoxicity 100%
  • Doxorubicin 81%
  • B-Lymphocytes 67%
  • Fc gamma receptor IIB 49%
  • Adoptive Transfer 13%

• Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes

  Ilahibaks, N. F., Kluiver, T. A., de Jong, O. G., de Jager, S. C. A., Schiffelers, R. M., Vader, P., Peng, W. C., Lei, Z. & Sluijter, J. P. G., Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, e12389.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Proprotein Convertase 9 100%
  • Ribonucleoproteins 84%
  • Extracellular Vesicles 80%
  • Clustered Regularly Interspaced Short Palindromic Repeats 78%
  • Hepatocytes 57%
  12 Downloads (Pure)

• Extracellular vesicles as vehicles for drug delivery to the heart

  Ilahibaks, N. F., Lei, Z. & Sluijter, J. P. G., 9 Jul 2024, In: European heart journal. 45, 26, p. 2273-2275 3 p.

  Research output: Contribution to journal › Article › Academic

• Factor XII contact activation can be prevented by targeting 2 unique patches in its epidermal growth factor-like 1 domain with a nanobody

  Frunt, R., El Otmani, H., Smits, S., Clark, C. C. & Maas, C., Sept 2024, In: Journal of thrombosis and haemostasis : JTH. 22, 9, p. 2562-2575 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Inter-laboratory multiplex bead-based surface protein profiling of MSC-derived EV preparations identifies MSC-EV surface marker signatures

  Nguyen, V. V. T., Welsh, J. A., Tertel, T., Choo, A., van de Wakker, S. I., Defourny, K. A. Y., Giebel, B., Vader, P., Padmanabhan, J., Lim, S. K., Nolte-'t Hoen, E. N. M., Verhaar, M. C., Bostancioglu, R. B., Zickler, A. M., Hong, J. M., Jones, J. C., EL Andaloussi, S., van Balkom, B. W. M. & Görgens, A., Jun 2024, In: Journal of Extracellular Vesicles. 13, 6, e12463.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Mesenchymal Stem Cells 76%
  • Membrane Proteins 70%
  • Quality Control 3%
  • Culture Media 3%

• Intracellular localisation and extracellular release of Y RNA and Y RNA binding proteins

  Driedonks, T. A. P., Ressel, S., Tran Ngoc Minh, T., Buck, A. H. & Nolte-'t Hoen, E. N. M., 16 Jan 2024, In: Journal of Extracellular Biology. 3, 1

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • RNA-Binding Proteins 97%
  • RNA 58%
  • RNA Transport 8%
  • Untranslated RNA 6%
  1 Downloads (Pure)

• Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease

  van Dijk, M. J., Ruiter, T. J. J., van der Veen, S., Rab, M. A. E., van Oirschot, B. A., Bos, J., Derichs, C., Rijneveld, A. W., Cnossen, M. H., Nur, E., Biemond, B. J., Bartels, M., Schutgens, R. E. G., van Solinge, W. W., Jans, J. J. M., van Beers, E. J. & van Wijk, R., Jun 2024, In: Hemasphere. 8, 6, e109.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • mitapivat 100%
  • Pyruvate Kinase 50%
  • Metabolome 43%
  • Sickle Cell Anemia 42%
  • 2,3-Diphosphoglycerate 16%

• Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

  Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., M˜y, G. M., Mohanty, S., Möller, A., Nieuwland, R., Ochiya, T., & 20 othersSahoo, S., Torrecilhas, A. C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E. M., Brucale, M., Burger, D., Carney, R. P., Cocucci, E., Crescitelli, R., Hanser, E., Harris, A. L., Haughey, N. J., Hendrix, A., Ivanov, A. R., Jovanovic-Talisman, T. & Kruh-Garcia, N. A., 7 Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, 84 p., e12404.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Research Personnel 8%
  • Body Fluids 6%
  • Advisory Committees 6%
  • Terminology 6%

• Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

  Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., Lopez, N. G., Mosquera, J. V., Auguste, G., Farber, E., Ma, W. F., Wong, D., Onengut-Gumuscu, S., Kavousi, M., Peyser, P. A., van der Laan, S. W., Leeper, N. J., Kovacic, J. C., Björkegren, J. L. M. & Miller, C. L., 10 Jan 2024, In: Cell genomics. 4, 1, 100465.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Blood Pressure 100%
  • Coronary Artery Disease 65%
  • Genome-Wide Association Study 49%
  • Coronary Vessels 38%
  • Genes 31%

• Omega-3 supplementation changes the physical properties of leukocytes but not erythrocytes in healthy individuals: An exploratory trial

  Schuchardt, J. P., Kräter, M., Schlögel, M., Guck, J., van Oirschot-Hermans, B. A., Bos, J., van Wijk, R., Tintle, N. L., Westra, J., Kerlikowsky, F., Hahn, A. & Harris, W. S., Mar 2024, In: Prostaglandins Leukotrienes and Essential Fatty Acids. 202, 10 p., 102636.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Osmotic gradient ektacytometry – a novel diagnostic approach for neuroacanthocytosis syndromes

  Hernández, C. A., Peikert, K., Qiao, M., Darras, A., de Wilde, J. R. A., Bos, J., Leibowitz, M., Galea, I., Wagner, C., Rab, M. A. E., Walker, R. H., Hermann, A., van Beers, E. J., van Wijk, R. & Kaestner, L., 18 Jul 2024, In: Frontiers in Neuroscience. 18, 9 p., 1406969.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Oxygen gradient ektacytometry-derived biomarkers are associated with acute complications in sickle cell disease

  Rab, M. A. E., Kanne, C. K., Boisson, C., Bos, J., van Oirschot, B. A., Houwing, M., Renoux, C., Bartels, M., Rijneveld, A. W., Nur, E., Cnossen, M. H., Joly, P., Nader, E., Fort, R., Connes, P., van Wijk, R., Sheehan, V. A. & van Beers, E. J., 23 Jan 2024, In: Blood Advances. 8, 2, p. 276-286 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Sickle Cell Anemia 100%
  • Oxygen 65%
  • Biomarkers 59%
  • Odds Ratio 58%
  • voxelotor 33%
  8 Downloads (Pure)

• Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis

  El Otmani, H., Frunt, R., Smits, S., Barendrecht, A. D., de Maat, S., Fijnheer, R., Lenting, P. J. & Tersteeg, C., 16 May 2024, In: Blood. 143, 20, p. 2089-2098 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles

  Cahalane, R. M. E., Turner, M. E., Clift, C. L., Blaser, M. C., Bogut, G., Levy, S., Kasai, T., Driedonks, T. A. P., Nolte-‘T Hoen, E. N. M., Aikawa, M., Singh, S. A. & Aikawa, E., Mar 2024, In: Journal of Visualized Experiments. 2024, 205, e66126.

  Research output: Contribution to journal › Article › Academic › peer-review

  • polycarbonate 100%
  • Proteomics 94%
  • Polycarbonates 86%
  • Extracellular Vesicles 84%
  • Proteins 65%

• Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis

  Prapiadou, S., Živković, L., Thorand, B., George, M. J., van der Laan, S. W., Malik, R., Herder, C., Koenig, W., Ueland, T., Kleveland, O., Aukrust, P., Gullestad, L., Bernhagen, J., Pasterkamp, G., Peters, A., Hingorani, A. D., Rosand, J., Dichgans, M., Anderson, C. D. & Georgakis, M. K., 27 Feb 2024, In: Circulation. 149, 9, p. 669-683 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Proteogenomics 100%
  • Chemokine CXCL10 84%
  • Atherosclerosis 48%
  • Interleukin-6 46%
  • Interleukin-6 Receptors 33%

• Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis

  van Kammen, C. M., Taal, S. E. L., Wever, K. E., Granger, J. P., Lely, A. T. & Terstappen, F., May 2024, In: American journal of physiology. Heart and circulatory physiology. 327, 1, p. H89-H107

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Fetal Growth Retardation 100%
  • Pre-Eclampsia 90%
  • Perfusion 68%
  • Meta-Analysis 67%
  • Systematic Reviews 67%

• Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

  Mocci, G., Sukhavasi, K., Örd, T., Bankier, S., Singha, P., Arasu, U. T., Agbabiaje, O. O., Mäkinen, P., Ma, L., Hodonsky, C. J., Aherrahrou, R., Muhl, L., Liu, J., Gustafsson, S., Byandelger, B., Wang, Y., Koplev, S., Lendahl, U., Owens, G. K., Leeper, N. J., & 15 othersPasterkamp, G., Vanlandewijck, M., Michoel, T., Ruusalepp, A., Hao, K., Ylä-Herttuala, S., Väli, M., Järve, H., Mokry, M., Civelek, M., Miller, C. J., Kovacic, J. C., Kaikkonen, M. U., Betsholtz, C. & Björkegren, J. L. M., 24 May 2024, In: Circulation research. 134, 11, p. 1405-1423 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Gene Regulatory Networks 100%
  • Atherosclerosis 74%
  • Smooth Muscle Myocytes 69%
  • Coronary Artery Disease 43%
  • Macrophages 36%
  1 Downloads (Pure)

• Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses

  van de Wakker, S., Bauzá-Martinez, J., Rios Arceo, C., Manjikian, H., Snijders Blok, C. J. B., Roefs, M., Maas, R. G., Willms, E., Pronker, M. F., de Jong, O., Wu, W., Görgens, A., Andaloussi, S. E. L., Sluijter, J. & Vader, P., 13 Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, 21 p., 12396.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Stem Cells 62%
  • Proteasome Endopeptidase Complex 44%
  • Gel Chromatography 42%
  • Proteins 15%
  1 Downloads (Pure)

• Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1

  Cornel, A. M., van der Sman, L., van Dinter, J. T., Arrabito, M., Dunnebach, E., van Hoesel, M., Kluiver, T. A., Lopes, A. P., Dautzenberg, N. M. M., Dekker, L., van Rijn, J. M., van den Beemt, D. A. M. H., Buhl, J. L., du Chatinier, A., Barneh, F., Lu, Y., Lo Nigro, L., Krippner-Heidenreich, A., Sebestyén, Z., Kuball, J., & 6 othersHulleman, E., Drost, J., van Heesch, S., Heidenreich, O. T., Peng, W. C. & Nierkens, S., 21 Mar 2024, In: Journal for ImmunoTherapy of Cancer. 12, 3, 15 p., e007538.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Histocompatibility Antigens Class I 100%
  • Pediatrics 54%
  • T-Lymphocytes 52%
  • Neoplasms 27%
  • HLA Antigens 17%
  3 Downloads (Pure)

• The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients

  20 Apr 2024, In: Scientific Reports. 14, 1, 9 p., 9113.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Critical Illness 100%
  • Immunosuppressive Agents 89%
  • Adrenal Cortex Hormones 65%
  • tocilizumab 50%
  • Interleukin 1 Receptor Antagonist Protein 48%

• Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions

  Lan, T., Palm, K. C. A., Hoeben, L., Diez Benavente, E., Perry, R. N., Civelek, M., de Kleijn, D. P. V., den Ruijter, H. M., Pasterkamp, G. & Mokry, M., Oct 2024, In: Atherosclerosis. 397, 10 p., 118554.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

  Fang, J., Yang, Q., Maas, R. G. C., Buono, M., Meijlink, B., Lotgerink Bruinenberg, D., Benavente, E. D., Mokry, M., van Mil, A., Qian, L., Goumans, M-J., Schiffelers, R., Lei, Z. & Sluijter, J. P. G., 17 Jan 2024, In: Stem Cell Research & Therapy [E]. 15, 1, p. 19 19.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Vitamin C 100%
  • Ascorbic Acid 82%
  • Reactive Oxygen Metabolite 78%
  • Reactive Oxygen Species 66%
  • Fibroblasts 49%
• 2023

  Acquired blood platelet disorder in patients with end-stage heart failure after implantation of a continuous centrifugal-flow left ventricular assist device: A prospective cohort study

  Liesdek, O. C. D., Schutgens, R. E. G., de Heer, L. M., Ramjankhan, F. Z., Sebastian, S. A. E., Rohof, J. J., Suyker, W. J. L. & Urbanus, R. T., Feb 2023, In: Research and practice in thrombosis and haemostasis. 7, 2, 8 p., 100101.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Blood Platelet Disorders 100%
  • Heart-Assist Devices 67%
  • Heart Failure 41%
  • Cohort Studies 38%
  • Prospective Studies 36%
  7 Downloads (Pure)

• Adeno-associated virus 2 infection in children with non-A–E hepatitis

  Imperial College London, 30 May 2023, In: Nature. 617, 7961, p. 555-563 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Adeno-associated virus-2 100%
  • Hepatitis 62%
  • Virus Diseases 48%
  • HLA Antigens 40%
  • Disease Outbreaks 35%
  8 Citations (Scopus)

• An automatic entropy method to efficiently mask histology whole-slide images

  Song, Y., Cisternino, F., Mekke, J. M., de Borst, G. J., de Kleijn, D. P. V., Pasterkamp, G., Vink, A., Glastonbury, C. A., van der Laan, S. W. & Miller, C. L., 15 Mar 2023, In: Scientific Reports. 13, 1, 4321.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Entropy 100%
  • Masks 87%
  • Histology 66%
  • Atherosclerotic Plaques 34%
  • Machine Learning 18%
  11 Downloads (Pure)

• An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood

  Rodriguez, B. V., Wen, Y., Shirk, E. N., Vazquez, S., Gololobova, O., Maxwell, A., Plunkard, J., Castell, N., Carlson, B., Queen, S. E., Izzi, J. M., Driedonks, T. A. P. & Witwer, K. W., 4 Dec 2023, In: Journal of Extracellular Vesicles. 12, 12, 14 p., 12368.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Blood Cells 69%
  • Macaca nemestrina 64%
  • B-Lymphocytes 21%
  • Intravenous Administration 13%
  6 Downloads (Pure)

• A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia

  van Dijk, M. J., van Oirschot, B. A., Harrison, A. N., Recktenwald, S. M., Qiao, M., Stommen, A., Cloos, A. S., Vanderroost, J., Terrasi, R., Dey, K., Bos, J., Rab, M. A. E., Bogdanova, A., Minetti, G., Muccioli, G. G., Tyteca, D., Egée, S., Kaestner, L., Molday, R. S., van Beers, E. J., & 1 othersvan Wijk, R., Dec 2023, In: American Journal of Hematology. 98, 12, p. 1877-1887 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Congenital Hemolytic Anemia 100%
  • Phosphatidylserines 71%
  • Adenosine Triphosphatases 62%
  • Phospholipids 55%
  • Erythrocytes 48%
  11 Downloads (Pure)

• Antibody deficiencies in children are associated with prematurity and a family history of infections

  Koenen, M. H., van Montfrans, J. M., Prevaes, S. M. P. J., van Engelen, M. P., van der Vries, E., Boes, M., Sanders, E. A. M., Bogaert, D. & Verhagen, L. M., Dec 2023, In: Pediatric Research. 94, 6, p. 2047-2053 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Antibodies 100%
  • Respiratory Tract Infections 95%
  • Infections 86%
  • Child 78%
  • Genetic Predisposition to Disease 26%

• Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration

  Muffels, I. J. J., Schene, I. F., Rehmann, H., Massink, M. P. G., van der Wal, M. M., Bauder, C., Labeur, M., Armando, N. G., Lequin, M. H., Houben, M. L., Giltay, J. C., Haitjema, S., Huisman, A., Vansenne, F., Bluvstein, J., Pappas, J., Shailee, L. V., Zarate, Y. A., Mokry, M., van Haaften, G. W., & 5 othersNieuwenhuis, E. E. S., Refojo, D., van Wijk, F., Fuchs, S. A. & van Hasselt, P. M., 5 Jan 2023, In: American Journal of Human Genetics. 110, 1, p. 146-160 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Lymphopenia 100%
  • Intellectual Disability 77%
  • Genetic Pleiotropy 64%
  • Cell Death 62%
  • Fibroblasts 60%

• Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

  Akbalut, C., Arisz, R., Baaten, C., Baildildinova, G., Barakzie, A., Bauersachs, R., Ten Berg, J. M., van den Broek, W., de Boer, H. C., Broker, V., Buka, R., Ten Cate, H., Cate, A. T., De Luca, C., De Simone, I., Dignat-George, F., Freson, K., Gazzaniga, G., van Gorp, E., Habibi, A., & 40 othersHenskens, Y. M. C., Iding, A. F. J., Khan, A., Koenderink, G., Konkoth, A., Lacroix, R., Lahiri, T., Lam, W., Lamerton, R., Lorusso, R., Luo, Q., Maas, C., McCarty, O. J. T., van der Meijden, P., Meijers, J., Mohapatra, A., Nevo, N., Pallares Robles, A., Poncelet, P., Reinhardt, C., Ruf, W., Saraswat, R., Schonichen, C., Schutgens, R. E. G., Simioni, P., Spada, S., Spronk, H. M. H., Tazhibayeva, K., Thachil, J., Vacik-Diaz, R., Veninga, A., Verhamme, P., Visser, C., Watson, S. P., Wenzel, P., Willems, R., Willers, A., Zhang, P., Zifkos, K. & van Zonneveld, A-J., Aug 2023, In: Thrombosis and Haemostasis. 123, 8, p. 808-839 32 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Blood Coagulation 100%
  • Thrombosis 68%
  • Hemorrhage 40%
  • Factor XI 18%
  • Factor XII 17%
  4 Downloads (Pure)

• Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins

  Roefs, M. T., Bauzá-Martinez, J., van de Wakker, S. I., Qin, J., Olijve, W. T., Tuinte, R., Rozeboom, M., Snijders Blok, C., Mol, E. A., Wu, W., Vader, P. & Sluijter, J. P. G., 1 Aug 2023, In: Communications biology. 6, 1, 800.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • angiogenesis 100%
  • Extracellular Vesicles 96%
  • stem cells 81%
  • Iodixanol 73%
  • Stem Cells 59%
  23 Downloads (Pure)

• Cellular polyploidy in organ homeostasis and regeneration

  Fang, J., de Bruin, A., Villunger, A., Schiffelers, R., Lei, Z. & Sluijter, J. P. G., 1 Aug 2023, In: Protein & cell. 14, 8, p. 560-578 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Polyploidy 100%
  • Apoptotic 91%
  • Regeneration 66%
  • Homeostasis 58%
  • Diploidy 21%
  25 Downloads (Pure)

• Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

  Overmars, L. M., Mekke, J. M., van Solinge, W. W., De Jager, S. C. A., Hulsbergen-Veelken, C. A. R., Hoefer, I. E., de Kleijn, D. P. V., de Borst, G. J., van der Laan, S. W. & Haitjema, S., Jun 2023, In: Atherosclerosis Plus. 52, p. 32-40 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Carotid Endarterectomy 100%
  • Erythrocyte Indices 77%
  • Blood Cells 69%
  • Neutrophils 33%
  • Hemorrhage 27%
  6 Downloads (Pure)

• Clonal Proliferation Within Smooth Muscle Cells in Unstable Human Atherosclerotic Lesions

  Kawai, K., Sakamoto, A., Mokry, M., Ghosh, S. K. B., Kawakami, R., Xu, W., Guo, L., Fuller, D., Tanaka, T., Shah, P., Cornelissen, A., Sato, Y., Mori, M., Konishi, T., Vozenilek, A. E., Dhingra, R., Virmani, R., Pasterkamp, G. & Finn, A. V., 1 Dec 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43, 12, p. 2333-2347 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Biglycan 100%
  • Smooth Muscle Myocytes 97%
  • Tunica Intima 96%
  • X-Linked Genes 56%
  • Clone Cells 53%

• Comparison of cardiovascular biomarker expression in extracellular vesicles, plasma and carotid plaque for the prediction of MACE in CEA patients

  Verwer, M. C., Mekke, J., Timmerman, N., Waissi, F., Boltjes, A., Pasterkamp, G., de Borst, G. J. & de Kleijn, D. P. V., 18 Jan 2023, In: Scientific Reports. 13, 1, 1010.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Biomarkers 55%
  • Atherosclerotic Plaques 44%
  • Proteins 25%
  • Blood Proteins 25%
  9 Downloads (Pure)

• Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

  Mijnheer, G., Servaas, N. H., Leong, J. Y., Boltjes, A., Spierings, E., Chen, P., Lai, L., Petrelli, A., Vastert, S., de Boer, R. J., Albani, S., Pandit, A. & van Wijk, F., 2023, In: eLife. 12, e79016.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Juvenile Arthritis 100%
  • Regulatory T-Lymphocytes 83%
  • Antigen 70%
  • Clone Cells 66%
  • Molecular Cluster 54%
  10 Downloads (Pure)