Center for Translational Immunology (CTI) Research

Research output

Research output per year 1989 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 1046 Article
• 136 Review article
• 92 Meeting Abstract
• 80 Comment/Letter to the editor
• 177 More
  • 75 Doctoral thesis 1 (Research UU / Graduation UU)
  • 42 Letter
  • 18 Chapter
  • 17 Editorial
  • 5 Short survey
  • 5 Doctoral thesis 2 (Research NOT UU / Graduation UU)
  • 4 Literature review
  • 3 Preprint
  • 2 Inaugural speech
  • 2 Abstract
  • 2 Poster
  • 1 Book editing
  • 1 Special issue

Research output per year

Research output per year

Search results

• 2024

  A 21-bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course

  Bos, J. W., Groen, E. J. N., Otten, H. G., Budding, K., van Eijk, R. P. A., Curial, C., Kardol-Hoefnagel, T., Goedee, H. S., van den Berg, L. H. & van der Pol, W. L., Jun 2024, In: Journal of the Peripheral Nervous System. 29, 2, p. 193-201 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Genetic Promoter Regions 100%
  • Genotype 44%
  • Biomedical Research 41%
  • Complement C5 32%
  • Confidence Intervals 24%

• A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

  Venema, W. J., Hiddingh, S., van Loosdregt, J., Bowes, J., Balliu, B., de Boer, J. H., Ossewaarde-van Norel, J., Thompson, S. D., Langefeld, C. D., de Ligt, A., van der Veken, L. T., Krijger, P. H. L., de Laat, W. & Kuiper, J. J. W., 10 Jan 2024, In: Cell genomics. 4, 1, 100460.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Lethal 100%
  • Enhancer 99%
  • Autoimmune Diseases 72%
  • Single Nucleotide Polymorphism 70%
  • Genes 33%
  19 Downloads (Pure)

• A Genome-Wide Association Study of Respiratory Syncytial Virus Infection Severity in Infants

  Johnson, M., Chelysheva, I., Öner, D., McGinley, J., Lin, G-L., O'Connor, D., Robinson, H., Drysdale, S. B., Gammin, E., Vernon, S., Muller, J., Wolfenden, H., Westcar, S., Anguvaa, L., Thwaites, R. S., Bont, L., Wildenbeest, J., Martinón-Torres, F., Aerssens, J., Openshaw, P. J. M., & 1 othersPollard, A. J., 15 Mar 2024, In: The Journal of infectious diseases. 229, Supplement_1, p. S112-S119

  Research output: Contribution to journal › Article › Academic › peer-review

  • Respiratory Syncytial Virus Infections 100%
  • Respiratory Syncytial Viruses 90%
  • Genome-Wide Association Study 80%
  • Single Nucleotide Polymorphism 64%
  • Linear Models 30%

• Age-specific SARS-CoV-2 transmission differed from human rhinovirus in households during the early COVID-19 pandemic

  Boom, T. T., de Hoog, M. L. A., Westerhof, I., Jaddoe, V., Heuvelman, V. D., Fourie, E., Sluiter-Post, J. G. C., Badoux, P., Euser, S., Herpers, B., Sanders, E. A. M., Eggink, D., Reusken, C., Bont, L. J., Wildenbeest, J. G., van Houten, M. A., Duijts, L. & Bruijning-Verhagen, P. C. J. L., Aug 2024, In: The Journal of Infection. 89, 2, 7 p., 106218.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Rhinovirus 88%
  • Pandemics 72%
  • Viruses 15%
  • Child 13%

• Airway and Blood Monocyte Transcriptomic Profiling Reveals an Antiviral Phenotype in Infants With Severe Respiratory Syncytial Virus Infection

  15 Mar 2024, In: The Journal of infectious diseases. 229, Supplement_1, p. S100-S111 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Respiratory Syncytial Virus Infections 100%
  • Antiviral Agents 66%
  • Monocytes 63%
  • Respiratory Syncytial Viruses 56%
  • Phenotype 46%

• Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma

  Gay, A. C. A., Banchero, M., Carpaij, O., Kole, T. M., Apperloo, L., van Gosliga, D., Fajar, P. A., Koppelman, G. H., Bont, L., Hendriks, R. W., van den Berge, M. & Nawijn, M. C., 19 Aug 2024, In: Thorax. 79, p. 811-821 thorax-2023-220230.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Goblet Cells 100%
  • Respiratory Syncytial Viruses 98%
  • Respiratory Syncytial Virus Infections 67%
  • Asthma 64%
  • Epithelial Cells 59%

• Allergenicity assessment of new or modified protein-containing food sources and ingredients

  Crevel, R. W. R., Verhoeckx, K., Bøgh, K. L., Buck, N., Chentouf, A., Flanagan, S., Galano, M., Garthoff, J. A., Hazebrouck, S., Yarham, R., Borja, G. & Houben, G., Jul 2024, In: Food and Chemical Toxicology. 189, 114766.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Food Ingredients 100%
  • allergenicity 91%
  • protein sources 69%
  • acceptable risk 63%
  • ingredients 58%

• Allogeneic haematopoietic cell transplantation for therapy-related myeloid neoplasms arising following treatment for lymphoma: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

  Nabergoj, M., Eikema, D-J., Koster, L., Platzbecker, U., Sockel, K., Finke, J., Kröger, N., Forcade, E., Nagler, A., Eder, M., Tischer, J., Broers, A. E. C., Kuball, J., Wilson, K. M. O., Hunault-Berger, M., Collin, M., Russo, D., Corral, L. L., Helbig, G., Mussetti, A., & 7 othersScheid, C., Gurnari, C., Raj, K., Drozd-Sokolowska, J., Yakoub-Agha, I., Robin, M. & McLornan, D. P., Mar 2024, In: Bone Marrow Transplantation. 59, 3, p. 395-402 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Second Primary Neoplasms 100%
  • Cell Transplantation 94%
  • Allogeneic Cells 94%
  • Cell- and Tissue-Based Therapy 83%
  • Lymphoma 72%

• Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss

  Krog, M. C., Flachs, E. M., Kolte, A. M., de Jager, W., Meyaard, L., Christiansen, O. B., Steffensen, R., Vomstein, K., Garred, P. & Nielsen, H. S., Jun 2024, In: Journal of Reproductive Immunology. 163, p. 1-8 8 p., 104221.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Mannose-Binding Lectin Complement Pathway 100%
  • Angiogenesis Inducing Agents 69%
  • Pregnancy 37%
  • Mannose-Binding Lectin 25%
  • ficolin 20%
  1 Downloads (Pure)

• Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis

  Gillard, J., Suffiotti, M., Brazda, P., Venkatasubramanian, P. B., Versteegen, P., de Jonge, M. I., Kelly, D., Bibi, S., Pinto, M. V., Simonetti, E., Babiceanu, M., Kettring, A., Teodosio, C., de Groot, R., Berbers, G., Stunnenberg, H. G., Schanen, B., Fenwick, C., Huynen, M. A. & Diavatopoulos, D. A., 8 Mar 2024, In: Nature Communications. 15, 1, p. 1-17 17 p., 2133.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • diphtheria 100%
  • Bordetella pertussis 65%
  • Diphtheria 64%
  • Poliovirus 62%
  • Whooping Cough 60%
  1 Downloads (Pure)

• Association of autoantibodies with the IFN signature and NETosis in patients with systemic lupus erythematosus

  Kaan, E. D., Brunekreef, T. E., Drylewicz, J., van den Hoogen, L. L., van der Linden, M., Leavis, H. L., van Laar, J. M., van der Vlist, M., Otten, H. G. & Limper, M., Dec 2024, In: Journal of translational autoimmunity. 9, 100246.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Traps 100%
  • Systemic Lupus Erythematosus 95%
  • Autoantibodies 93%
  • Interferons 93%
  • Interferon Type I 12%

• Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial

  Jun 2024, In: EClinicalMedicine. 72, 102616.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Vaccination 100%
  • Fever 93%
  • Denmark 26%
  • Health Personnel 21%
  • Control Groups 20%
  2 Downloads (Pure)

• B-cell precursor acute lymphoblastic leukemia elicits an interferon-α/b response in bone marrow-derived mesenchymal stroma

  Smeets, M. W. E., Steeghs, E. M. P., Orsel, J., Stalpers, F., Vermeeren, M. M. P., Veltman, C. H. J., Slenders, L., Nierkens, S., Van de Ven, C. & Den Boer, M. L., Jul 2024, In: Haematologica. 109, 7, p. 2073-2084 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • B-Lymphoid Precursor Cells 100%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 81%
  • Interferons 76%
  • Bone Marrow 60%
  • Mesenchymal Stem Cells 40%

• BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response

  Alieva, M., Barrera Román, M., de Blank, S., Petcu, D., Zeeman, A. L., Dautzenberg, N. M. M., Cornel, A. M., van de Ven, C., Pieters, R., den Boer, M. L., Nierkens, S., Calkoen, F. G. J., Clevers, H., Kuball, J., Sebestyén, Z., Wehrens, E. J., Dekkers, J. F. & Rios, A. C., Jul 2024, In: Nature protocols. 19, 7, p. 2052-2084 33 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Pipeline 100%
  • T-Lymphocytes 53%
  • Coculture Techniques 43%
  • Heterogeneity 39%
  • Immunotherapy 38%

• Bridging the gap between scientific discoveries and clinical application at the Utrecht Science Park

  Peperzak, V. & Coquet, J. M., Apr 2024, In: Immunology and Cell Biology. 102, 4, p. 232-234 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Netherlands 100%

• Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy

  Kenmoe, S., Chu, H. Y., Dawood, F. S., Milucky, J., Kittikraisak, W., Matthewson, H., Kulkarni, D., Suntarattiwong, P., Frivold, C., Mohanty, S., Havers, F., Li, Y., Nair, H. & Bont, L., 15 Mar 2024, In: Journal of Infectious Diseases. 229, p. S51-S60

  Research output: Contribution to journal › Article › Academic › peer-review

  • Respiratory Syncytial Viruses 100%
  • Respiratory Tract Infections 78%
  • Pregnancy 51%
  • Respiratory Syncytial Virus Vaccines 20%
  • Hospitalization 14%

• Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration

  Labonia, M. C. I., Estapé Senti, M., van der Kraak, P. H., Brans, M. A. D., Dokter, I., Streef, T. J., Smits, A. M., Deshantri, A. K., de Jager, S. C. A., Schiffelers, R. M., Sluijter, J. P. G. & Vader, P., May 2024, In: Journal of controlled release : official journal of the Controlled Release Society. 369, p. 734-745 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Messenger RNA 100%
  • Nanoparticles 80%
  • Lipid 62%
  • Lipids 59%
  • Nanoparticle 45%
  1 Downloads (Pure)

• CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders

  Picavet, L. W., Samat, A. A. K., Calis, J., Nijhuis, L., Scholman, R., Mokry, M., Tough, D. F., Prinjha, R. K., Vastert, S. J. & van Loosdregt, J., 18 Jun 2024, In: Biomedicines. 12, 6, 14 p., 1344.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • CREB-Binding Protein 100%
  • Disorder 58%
  • T-Lymphocytes 42%
  • Juvenile Arthritis 32%
  • Protein 28%

• CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-β signaling driving myelofibrosis

  Leguit, R. J., Broekhuizen, R., de Witte, M., Raymakers, R. A. P. & Goldschmeding, R., May 2024, In: Virchows Archives. 484, 5, p. 837-845 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Connective Tissue Growth Factor 100%
  • Primary Myelofibrosis 94%
  • Communication 56%
  • Fibrosis 56%
  • Neoplasms 24%
  1 Downloads (Pure)

• Changes in the global hospitalisation burden of respiratory syncytial virus in young children during the COVID-19 pandemic: a systematic analysis

  Apr 2024, In: The Lancet Infectious Diseases. 24, 4, p. 361-374 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Respiratory Syncytial Viruses 100%
  • Pandemics 90%
  • Income 69%
  • Hospitalization 62%
  • Child 36%
  1 Downloads (Pure)

• Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior

  Jansen, S. A., Cutilli, A., de Koning, C., van Hoesel, M., Frederiks, C. L., Saiz Sierra, L., Nierkens, S., Mokry, M., Nieuwenhuis, E. E. S., Hanash, A. M., Mocholi, E., Coffer, P. J. & Lindemans, C. A., 21 Jun 2024, In: iScience. 27, 6, p. 1-19 19 p., 110072.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Galectins 100%
  • Organoids 94%
  • T-Lymphocytes 44%
  • Drug Therapy 42%
  • Cell Proliferation 28%

• Clinical presentation and outcome of invasive mould disease in paediatric patients with acute lymphoblastic leukaemia

  Bury, D., Parmentier, C. E. J., Tissing, W. J. E., Pieters, R., Bont, L. J., Brüggemann, R. J. & Wolfs, T. F. W., Jun 2024, In: EJC Paediatric Oncology. 3, p. 1-5 5 p., 100143.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 100%
  • Fungi 91%
  • Pediatrics 65%
  • Aspergillosis 15%
  • Neuroimaging 11%
  2 Downloads (Pure)

• Combining Cellular Immunization and Phage Display Screening Results in Novel, FcγRI-Specific Antibodies

  Krohn, S., Holtrop, T., Brandsma, A. M., Moerer, P., Nederend, M., Darzentas, N., Brüggemann, M., Klausz, K., Leusen, J. H. W. & Peipp, M., 12 Apr 2024, In: Viruses. 16, 4, 13 p., 596.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Bacteriophages 100%
  • Hybridomas 86%
  • Immunization 85%
  • Antibodies 55%
  • Monoclonal Antibodies 55%
  1 Downloads (Pure)

• Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML

  Lo Presti, V., Meringa, A., Dunnebach, E., van Velzen, A., Moreira, A. V., Stam, R. W., Kotecha, R. S., Krippner-Heidenreich, A., Heidenreich, O. T., Plantinga, M., Cornel, A., Sebestyen, Z., Kuball, J., van Til, N. P. & Nierkens, S., 5 Apr 2024, In: Journal for ImmunoTherapy of Cancer. 12, 4, 15 p., e008174.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • T-Cell Antigen Receptor 88%
  • Fetal Blood 85%
  • Acute Myeloid Leukemia 83%
  • Wilms Tumor 69%
  10 Downloads (Pure)

• Cord blood transplantation for AML: Comparable LFS in patients with de novo versus secondary AML in CR1, an ALWP/EBMT study

  Baron, F., Nagler, A., Galimard, J-E., Sanz, J., Versluis, J., Forcade, E., Chevallier, P., Sirvent, A., Anthias, C., Kuball, J., Furst, S., Rambaldi, A., Sierra, J., von dem Borne, P. A., Gallego Hernanz, M. P., Cluzeau, T., Robinson, S., Raiola, A. M., Labussière-Wallet, H., Byrne, J. L., & 4 othersMalfuson, J-V., Ruggeri, A., Mohty, M. & Ciceri, F., Jan 2024, In: British Journal of Haematology. 204, 1, p. 250-259 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Fetal Blood 100%
  • Acute Myeloid Leukemia 96%
  • Leukemia 82%
  • Transplantation 77%
  • Survival 56%

• Current challenges in cell and gene therapy: a joint view from the European Committee of the International Society for Cell & Gene Therapy (ISCT) and the European Society for Blood and Marrow Transplantation (EBMT)

  Sanchez-Guijo, F., Vives, J., Ruggeri, A., Chabannon, C., Corbacioglu, S., Dolstra, H., Farge, D., Gagelmann, N., Horgan, C., Kuball, J., Neven, B., Rintala, T., Rocha, V., Sanchez-Ortega, I., Snowden, J. A., Zwaginga, J. J., Gnecchi, M. & Sureda, A., Jul 2024, In: Cytotherapy. 26, 7, p. 681-685 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cell- and Tissue-Based Therapy 100%
  • Genetic Therapy 97%
  • Transplantation 80%
  • Bone Marrow 77%
  • Joints 74%
  1 Downloads (Pure)

• Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation

  Kardol-Hoefnagel, T., Senejohnny, D. M., Kamburova, E. G., Wisse, B. W., Reteig, L., Gruijters, M. L., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C. A. D., Plaisier, L., Melchers, R. C. A., & 30 othersSeelen, M. A. J., Sanders, J. S., Hepkema, B. G., Lambeck, A. J. A., Bungener, L. B., Roozendaal, C., Tilanus, M. G. J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M. A. C. J., Christiaans, M. H. L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A. M. I., van der Weerd, N. C., Ten Berge, I. J. M., Hoitsma, A., van der Boog, P. J. M., de Fijter, J. W., Betjes, M. G. H., Roelen, D. L., Claas, F. H., Bemelman, F. J., Senev, A., Naesens, M., Heidt, S. & Otten, H. G., Jan 2024, In: HLA. 103, 1, e15346.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Kidney Transplantation 100%
  • Epitopes 90%
  • Antibodies 58%
  • Tissue Donors 48%
  • Graft Survival 13%
  3 Downloads (Pure)

• Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells

  Hernández-López, P., van Diest, E., Brazda, P., Heijhuurs, S., Meringa, A., Hoorens van Heyningen, L., Riillo, C., Schwenzel, C., Zintchenko, M., Johanna, I., Nicolasen, M. J. T., Cleven, A., Kluiver, T. A., Millen, R., Zheng, J., Karaiskaki, F., Straetemans, T., Clevers, H., de Bree, R., Stunnenberg, H. G., & 6 othersPeng, W. C., Roodhart, J., Minguet, S., Sebestyén, Z., Beringer, D. X. & Kuball, J., Jan 2024, In: Nature immunology. 25, 1, p. 88-101 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Metabolome 100%
  • Antigens 56%
  • T-Lymphocytes 54%
  • T-Cell Antigen Receptor 45%
  • Neoplasms 28%

• Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study

  Jun 2024, In: The lancet. HIV. 11, 6, p. e389-e405

  Research output: Contribution to journal › Article › Academic › peer-review

  • Hematopoietic Stem Cell Transplantation 100%
  • Observational Studies 72%
  • HIV 64%
  • Cohort Studies 63%
  • HIV Antibodies 24%

• EAACI task force report: A consensus protocol for the basophil activation test for collaboration and external quality assurance

  Pascal, M., Edelman, S. M., Nopp, A., Möbs, C., Geilenkeuser, W. J., Knol, E. F., Ebo, D. G., Mertens, C., Shamji, M. H., Santos, A. F., Patil, S., Eberlein, B., Mayorga, C. & Hoffmann, H. J., Feb 2024, In: Allergy. 79, 2, p. 290-293 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Effectiveness of Immunization Products Against Medically Attended Respiratory Syncytial Virus Infection: Generic Protocol for a Test-Negative Case-Control Study

  Roekel, C. V., Poukka, E., Turunen, T., Nohynek, H., Presser, L., Meijer, A., Heikkinen, T., Kramer, R., Begier, E., Teirlinck, A. C., Knol, M. & Bont, L., 15 Mar 2024, In: Journal of Infectious Diseases. 229, p. S92-S99

  Research output: Contribution to journal › Article › Academic › peer-review

• Effectiveness of Vaccines and Monoclonal Antibodies Against Respiratory Syncytial Virus: Generic Protocol for Register-Based Cohort Study

  Poukka, E., Roekel, C. V., Turunen, T., Baum, U., Kramer, R., Begier, E., Presser, L. D., Teirlinck, A. C., Heikkinen, T., Knol, M., Nohynek, H. & Bont, L., 15 Mar 2024, In: Journal of Infectious Diseases. 229, p. S84-S91

  Research output: Contribution to journal › Article › Academic › peer-review

• Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

  Kardol-Hoefnagel, T., Senejohnny, D. M., Kamburova, E. G., Wisse, B. W., Gruijters, M. L., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Drop, A. C. A. D., Plaisier, L., Melchers, R. C. A., Seelen, M. A. J., Sanders, J. S., & 26 othersHepkema, B. G., Kroesen, B. J., Bungener, L. B., Roozendaal, C., Tilanus, M. G. J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M. A. C. J., Christiaans, M. H. L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A. M. I., van der Weerd, N. C., ten Berge, I. J. M., Hoitsma, A., van der Boog, P. J. M., de Fijter, J. W., Betjes, M. G. H., Roelen, D. L., Claas, F. H., Bemelman, F. J., Heidt, S. & Otten, H. G., Jan 2024, In: HLA. 103, 1, 6 p., e15297.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Graft Survival 100%
  • Epitopes 81%
  • Tissue Donors 62%
  • Transplants 59%
  • Antibodies 52%
  7 Downloads (Pure)

• Enhanced aortic stiffness in adolescents with chronic disease is associated with decreased left ventricular global longitudinal strain

  Verpalen, V. A., Ververs, F. A., Slieker, M., Nuboer, R., Swart, J. F., van der Ent, C. K., Fejzic, Z., Westenberg, J. J. M., Leiner, T., Grotenhuis, H. B. & Schipper, H. S., 1 Jun 2024, In: IJC Heart and Vasculature. 52, 101385.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Vascular Stiffness 100%
  • Pulse Wave Analysis 68%
  • Chronic Disease 63%
  • Left Ventricular Function 41%
  • Coenzyme A 35%
  1 Downloads (Pure)

• Enhancing IgA-mediated neutrophil cytotoxicity against neuroblastoma by CD47 blockade

  Chan, C., Stip, M., Nederend, M., Jansen, M., Passchier, E., van den Ham, F., Wienke, J., van Tetering, G. & Leusen, J., 23 May 2024, In: Journal for ImmunoTherapy of Cancer. 12, 5, e008478.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neuroblastoma 100%
  • Immunoglobulin A 93%
  • ch14.18 monoclonal antibody 82%
  • Neutrophils 78%
  • Immunoglobulin G 50%
  3 Downloads (Pure)

• Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

  van Boven, M., van Dorp, C. H., Westerhof, I., Jaddoe, V., Heuvelman, V., Duijts, L., Fourie, E., Sluiter-Post, J., van Houten, M. A., Badoux, P., Euser, S., Herpers, B., Eggink, D., de Hoog, M., Boom, T., Wildenbeest, J., Bont, L., Rozhnova, G., Bonten, M. J., Kretzschmar, M. E., & 1 othersBruijning-Verhagen, P., 29 Jan 2024, In: PLoS Computational Biology. 20, 1, 20 p., e1011832.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Severe Acute Respiratory Syndrome 100%
  • severe acute respiratory syndrome 98%
  • SARS Virus 94%
  • Hazard 71%
  • households 60%
  2 Downloads (Pure)

• Experimental Data on PIRCHE and T-Cell Reactivity: HLA-DPB1-Derived Peptides Identified by PIRCHE-I Show Binding to HLA-A*02:01 in vitro and T-Cell Activation in vivo

  Peereboom, E. T. M., Maranus, A. E., Timmerman, L. M., Geneugelijk, K. & Spierings, E., 2 Apr 2024, In: Transfusion Medicine and Hemotherapy. 51, 3, p. 132-140 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • HLA Antigens 100%
  • Peptides 62%
  • T-Lymphocytes 60%
  • In Vitro Techniques 42%
  • Graft vs Host Disease 25%
  1 Downloads (Pure)

• External Validation of the Discriminative Validity of the ReSVinet Score and Development of Simplified ReSVinet Scores in Secondary Care

  Sheikh, Z., Potter, E., Li, Y., Drysdale, S. B., Wildenbeest, J. G., Robinson, H., McGinley, J., Lin, G-L., Öner, D., Aerssens, J., Justicia-Grande, A. J., Martinón-Torres, F., Pollard, A. J., Bont, L. & Nair, H., 15 Mar 2024, In: The Journal of infectious diseases. 229, Supplement_1, p. S18-S24

  Research output: Contribution to journal › Article › Academic › peer-review

  • Secondary Care 100%
  • Datasets 64%
  • ROC Curve 41%
  • Respiratory Syncytial Viruses 38%
  • Rwanda 23%

• Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T-cells

  Zhang, X., Greve, P. F., Minh, T. T. N., Wubbolts, R., Demir, A. Y., Zaal, E. A., Berkers, C. R., Boes, M. & Stoorvogel, W., 16 Jul 2024, In: Journal of Extracellular Vesicles. 13, 7, p. 1-22 22 p., e12457.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Genome-wide Association Study of Susceptibility to Respiratory Syncytial Virus Hospitalization in Young Children <5 Years of age

  Egeskov-Cavling, A. M., Van Wijhe, M., Yakimov, V., Johannesen, C. K., Pollard, A., Trebbien, R., Bybjerg-Grauholm, J. & Fischer, T. K., 15 Aug 2024, In: Journal of Infectious Diseases. 230, 2, p. e333-e341

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

  30 Mar 2024, In: Lancet (London, England). 403, 10433, p. 1241-1253 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Global Burden of Disease 100%
  • Respiratory Syncytial Viruses 87%
  • Premature Infants 71%
  • Respiratory Tract Infections 69%
  • Meta-Analysis 55%

• Healthcare costs related to respiratory syncytial virus in paediatric intensive care units in the Netherlands: a nationwide prospective observational study (the BRICK study)

  Phijffer, E. W. E. M., Wildenbeest, J. G., Brouwer, C. N. M., de Hoog, M., Kneyber, M. C. J., Maebe, S., Nusmeier, A., Riedijk, M. A., Wösten-van Asperen, R. M., van Woensel, J. B. M., Bont, L. J. & Frederix, G. J. W., Aug 2024, In: The Lancet Regional Health - Europe. 43, 10 p., 100965.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Pediatric Intensive Care Units 100%
  • Respiratory Syncytial Viruses 97%
  • Netherlands 80%
  • Health Care Costs 74%
  • Observational Studies 64%
  2 Downloads (Pure)

• Heterozygous missense CSF1R variants hamper in vitro CD34+-derived dendritic cell generation but not in vivo dendritic cell development

  Beerepoot, S., Wolf, N. I., van der Knaap, M. S., Nierkens, S. & Plantinga, M., Oct 2024, In: Molecular Immunology. 174, p. 41-46 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• High-dose individualized antithymocyte globulin with therapeutic drug monitoring in high-risk cord blood transplant

  Admiraal, R., Versluijs, A. B., Huitema, A. D. R., Ebskamp, L., Lacna, A., de Kanter, C. T. K., Bierings, M. B., Boelens, J. J., Lindemans, C. A. & Nierkens, S., Jun 2024, In: Cytotherapy. 26, 6, p. 599-605 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Antilymphocyte Serum 100%
  • Drug Monitoring 91%
  • Fetal Blood 78%
  • Transplantation 60%
  • Graft vs Host Disease 58%

• Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

  Foss, S., Sakya, S. A., Aguinagalde, L., Lustig, M., Shaughnessy, J., Cruz, A. R., Scheepmaker, L., Mathiesen, L., Ruso-Julve, F., Anthi, A. K., Gjølberg, T. T., Mester, S., Bern, M., Evers, M., Bratlie, D. B., Michaelsen, T. E., Schlothauer, T., Sok, D., Bhattacharya, J., Leusen, J., & 5 othersValerius, T., Ram, S., Rooijakkers, S. H. M., Sandlie, I. & Andersen, J. T., Dec 2024, In: Nature Communications. 15, 1, 2007.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • antibodies 100%
  • bacteria 90%
  • half life 87%
  • Reaction Half Life 80%
  • cancer 79%
  1 Downloads (Pure)

• Humoral and cellular immunogenicity, effectiveness and safety of COVID-19 mRNA vaccination in patients with pediatric rheumatic diseases: A prospective cohort study

  Hamad Saied, M., van Straalen, J. W., de Roock, S., Verduyn Lunel, F. M., de Wit, J., de Rond, L. G. H., Van Nieuwenhove, E., Vastert, B. J., van Montfrans, J. M., van Royen-Kerkhof, A., de Joode-Smink, G. C. J., Swart, J. F., Wulffraat, N. M. & Jansen, M. H. A., 15 Feb 2024, In: Vaccine. 42, 5, p. 1145-1153 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • cohort studies 100%
  • pediatrics 92%
  • immunogenicity 86%
  • vaccination 81%
  • Rheumatic Diseases 77%
  2 Downloads (Pure)

• Identifying clinical response to daratumumab therapy in relapsed/refractory multiple myeloma using a patient-derived in vitro model

  van Nieuwenhuijzen, N., Cuenca, M., Abbink, L., Jak, M., Peperzak, V. & Minnema, M. C., Feb 2024, In: EJHaem. 5, 1, p. 141-146 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • daratumumab 100%
  • Multiple Myeloma 58%
  • Hydrogels 31%
  • In Vitro Techniques 25%
  • Progression-Free Survival 13%
  1 Downloads (Pure)

• IgG1 glycosylation highlights premature aging in Down syndrome

  Jul 2024, In: Aging Cell. 23, 7, e14167.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Premature Aging 100%
  • Down Syndrome 77%
  • Glycosylation 77%
  • Immunoglobulin G 56%
  • SARS Virus 33%

• IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset

  Budding, K., Bos, J. W., Dijkxhoorn, K., de Zeeuw, E., Bloemenkamp, L. M., Zekveld, E. M., Groen, E. J. N., Jacobs, B. C., Huizinga, R., Goedee, H. S., Cats, E. A., Leusen, J. H. W., van den Berg, L. H., Hack, C. E. & van der Pol, W. L., 17 Apr 2024, In: Journal of Neuroinflammation. 21, 1, 14 p., 100.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Schwann Cells 100%
  • anti-IgM 97%
  • Immunoglobulin M 79%
  • Anti-Idiotypic Antibodies 75%
  • Motor Neurons 43%

• Impact of Subgroup Distribution on Seasonality of Human Respiratory Syncytial Virus: A Global Systematic Analysis

  Deng, S., Guo, L., Cohen, C., Meijer, A., Moyes, J., Pasittungkul, S., Poovorawan, Y., Teirlinck, A., van Boven, M., Wanlapakorn, N., Wolter, N., Paget, J., Nair, H., Li, Y. & Bont, L., 15 Mar 2024, In: Journal of Infectious Diseases. 229, p. S25-S33

  Research output: Contribution to journal › Article › Academic › peer-review