Center for Translational Immunology (CTI) Lab support

2024

A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

Venema, W. J., Hiddingh, S., van Loosdregt, J., Bowes, J., Balliu, B., de Boer, J. H., Ossewaarde-van Norel, J., Thompson, S. D., Langefeld, C. D., de Ligt, A., van der Veken, L. T., Krijger, P. H. L., de Laat, W. & Kuiper, J. J. W., 10 Jan 2024, In: Cell genomics. 4, 1, 100460.

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CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders

Picavet, L. W., Samat, A. A. K., Calis, J., Nijhuis, L., Scholman, R., Mokry, M., Tough, D. F., Prinjha, R. K., Vastert, S. J. & van Loosdregt, J., 18 Jun 2024, In: Biomedicines. 12, 6, 14 p., 1344.

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m⁶A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by Downregulating Membrane CX3CR1 Expression

Picavet, L. W., van Vroonhoven, E. C. N., Scholman, R. C., Smits, Y. T. H., Banerjee, R., Besteman, S. B., Viveen, M. C., van der Vlist, M. M., Tanenbaum, M. E., Lebbink, R. J., Vastert, S. J. & van Loosdregt, J., May 2024, In: Viruses. 16, 5, 14 p., 778.

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2023

Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis

Servaas, N. H., Hiddingh, S., Chouri, E., Wichers, C. G. K., Affandi, A. J., Ottria, A., Bekker, C. P. J., Cossu, M., Silva-Cardoso, S. C., van der Kroef, M., Hinrichs, A. C., Carvalheiro, T., Vazirpanah, N., Beretta, L., Rossato, M., Bonte-Mineur, F., Radstake, T. R. D. J., Kuiper, J. J. W., Boes, M. & Pandit, A., Feb 2023, In: Arthritis & Rheumatology. 75, 2, p. 279-292 14 p.

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Nuclear segmentation facilitates neutrophil migration

Shen, C., Mulder, E., Buitenwerf, W., Postat, J., Jansen, A., Kox, M., Mandl, J. N. & Vrisekoop, N., 1 Jun 2023, In: Journal of cell science. 136, 11, 7 p., jcs260768.

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Retina-arrestin specific CD8+ T cells are not implicated in HLA-A29-positive birdshot chorioretinitis

Venema, W. J., Hiddingh, S., Janssen, G. M. C., Ossewaarde-van Norel, J., van Loon, N. D., de Boer, J. H., van Veelen, P. A. & Kuiper, J. J. W., Feb 2023, In: Clinical Immunology. 247, p. 1-10 10 p., 109219.

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Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

Hiddingh, S., Pandit, A., Verhagen, F. H., Rijken, R., Servaas, N. H., Wichers, C. G. K., Ten Dam-Van Loon, N. H., Imhof, S. M., Radstake, T. R. D. J., de Boer, J. H. & Kuiper, J. J. W., 12 Apr 2023, In: eLife. 12, e74913.

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2021

Signaling by the inhibitory receptor CD200R is rewired by type I interferon

van der Vlist, M., Pascoal Ramos, M. I., van den Hoogen, L. L., Hiddingh, S., Timmerman, L. M., de Hond, T. A. P., Kaan, E. D., van der Kroef, M., Lebbink, R. J., Peters, F. M. A., Khoury-Hanold, W., Fritsch-Stork, R., Radstake, T. R. D. J. & Meyaard, L., 12 Oct 2021, In: Science Signaling [E]. 14, 704, p. 1-11 eabb4324.

Research output: Contribution to journal › Article › Academic › peer-review

2017

An Ocular Protein Triad Can Classify Four Complex Retinal Diseases

Kuiper, J. J. W., Beretta, L., Nierkens, S., Van Leeuwen, R., Ten Dam-Van Loon, N. H., Ossewaarde-Van Norel, J., De Groot-Mijnes, J. D. F., Schellekens, P., De Boer, J. H. & Radstake, T. R. D. J., 27 Jan 2017, In: Scientific Reports. 7, 41595.

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Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis

Admiraal, R., Nierkens, S., de Witte, M. A., Petersen, E. J., Fleurke, G-J., Verrest, L., Belitser, S. V., Bredius, R. G. M., Raymakers, R. A. P., Knibbe, C. A. J., Minnema, M. C., van Kesteren, C., Kuball, J. & Boelens, J. J., Apr 2017, In: Lancet haematology. 4, 4, p. e183–e191

Research output: Contribution to journal › Article › Academic › peer-review

Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis

Thijs, J. L., Strickland, I., Bruijnzeel-Koomen, C. A. F. M., Nierkens, S., Giovannone, B., Csomor, E., Sellman, B. R., Mustelin, T., Sleeman, M. A., de Bruin-Weller, M. S., Herath, A., Drylewicz, J., May, R. D. & Hijnen, D. J., Sept 2017, In: Journal of Allergy and Clinical Immunology. 140, 3, p. 730-737 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation

Admiraal, R., de Koning, C. C. H., Lindemans, C. A., Bierings, M. B., Wensing, A. M. J., Versluys, A. B., Wolfs, T. F. W., Nierkens, S. & Boelens, J. J., Dec 2017, In: Journal of Allergy and Clinical Immunology. 140, 6, p. 1643-1650.e9

Research output: Contribution to journal › Article › Academic › peer-review

2016

Excellent T-cell reconstitution and survival provided ATG exposure is low or absent after pediatric cord blood transplantation

Admiraal, R., Lindemans, C. A., van Kesteren, C., Bierings, M. B., Versluijs, A. B., Nierkens, S. & Boelens, J. J., 2016, In: Blood. 128, 23, p. 2734-2741

Research output: Contribution to journal › Article › Academic › peer-review

Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses.

Seyfizadeh, N., Muthuswamy, R., Mitchell, D., Nierkens, S. & Seyfizadeh, N., Nov 2016, In: Critical Reviews in Oncology Hematology. 107, p. 100-110

Research output: Contribution to journal › Article › Academic › peer-review

Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

van Montfrans, J. M., Hartman, E. A. R., Braun, K. P. J., Hennekam, E. A. M., Hak, E. A., Nederkoorn, P. J., Westendorp, W. F., Bredius, R. G. M., Kollen, W. J. W., Schölvinck, E. H., Elizabeth Legger, G., Meyts, I., Liston, A., Lichtenbelt, K. D., Giltay, J. C., Van Haaften, G., De Vries Simons, G. M., Leavis, H., Sanders, C. J. G., Bierings, M. B., & 2 othersNierkens, S. & Van Gijn, M. E., 1 May 2016, In: Rheumatology (Oxford, England). 55, 5, p. 902-910 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Strategies before, during, and after hematopoietic cell transplantation to improve T-cell immune-reconstitution

de Koning, C., Nierkens, S. & Boelens, J. J., 2016, In: Blood. 128, 23, p. 2607-2615

Research output: Contribution to journal › Article › Academic › peer-review

Systemic Inflammatory Immune Signatures in a Patient with CRB1 linked Retinal Dystrophy

Verhagen, F., Kuiper, J., Nierkens, S., Imhof, S. M., Radstake, T. & de Boer, J., 2016, In: Expert Review of Clinical Immunology. 12, 12, p. 1359-1362

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The magnitude of cytokine production by stimulated CD56+ cells is associated with early stages of systemic sclerosis

Cossu, M., van Bon, L., Nierkens, S., Bellocchi, C., Santaniello, A., Dolstra, H., Beretta, L. & Radstake, TRDJ., Dec 2016, In: Clinical Immunology. 173, p. 76-80

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2015

Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children

Janssen, W. J. M., Nierkens, S., Sanders, E. A., Boes, M. & van Montfrans, J. M., 17 Nov 2015, In: Vaccine. 33, 46, p. 6320-6326 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Challenges in the harmonization of immune monitoring studies and trial design for cell-based therapies in the context of hematopoietic cell transplantation for pediatric cancer patients

Nierkens, S., Lankester, A. C., Egeler, R. M., Bader, P., Locatelli, F., Pulsipher, M. A., Bollard, C. M. & Boelens, J. J., 1 Dec 2015, In: Cytotherapy. 17, 12, p. 1667-1674 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Cognate CD4 T-Cell Licensing of Dendritic Cells Heralds Anti-Cytomegalovirus CD8 T-Cell Immunity after Human Allogeneic Umbilical Cord Blood Transplantation

Flinsenberg, T. W. H., Spel, L., Jansen, M., Koning, D., de Haar, C., Plantinga, M., Scholman, R., van Loenen, M. M., Nierkens, S., Boon, L., van Baarle, D., Heemskerk, M. H. M., Boelens, J. J. & Boes, M., 15 Jan 2015, In: Journal of Virology. 89, 2, p. 1058-1069 12 p.

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Generation of a cord blood-derived Wilms Tumor 1 dendritic cell vaccine for AML patients treated with allogeneic cord blood transplantation

de Haar, C., Plantinga, M., Blokland, N. J. G., van Til, N. P., Flinsenberg, T. W. H., Van Tendeloo, V. F., Smits, E. L., Boon, L., Spel, L., Boes, M., Boelens, J. J. & Nierkens, S., Nov 2015, In: OncoImmunology. 4, 11, p. e1023973 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

Spel, L., Boelens, J. J., Van Der Steen, D. M., Blokland, N. J. G., van Noesel, M. M., Molenaar, J. J., Heemskerk, M. H. M., Boes, M. & Nierkens, S., 2015, In: Oncotarget. 6, 34, p. 35770-35781 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

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Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

Van Montfrans, J., Hartman, E., Braun, K., Hennekam, F., Hak, A., Nederkoorn, P., Westendorp, W., Bredius, R., Kollen, W., Scholvinck, E., Legger, G., Meyts, I., Liston, A., Lichtenbelt, K., Giltay, J., Van Haaften, G., De Vries Simons, G., Leavis, H., Nierkens, S., Sanders, C., & 1 othersVan Gijn, M., 28 Sept 2015, In: Pediatric Rheumatology. 13, 1, O7.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2014

A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma

Kroesen, M., Nierkens, S., Ansems, M., Wassink, M., Orentas, R. J., Boon, L., den Brok, M. H., Hoogerbrugge, P. M. & Adema, G. J., 2014, In: International Journal of Cancer. 134, 6, p. 1335-45 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

2012

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

Jacobs, J. F. M., Nierkens, S., Figdor, C. G., de Vries, I. J. M. & Adema, G. J., Jan 2012, In: LANCET ONCOLOGY. 13, 1, p. e32-42

Research output: Contribution to journal › Article › Academic › peer-review

Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined with in situ tumor destruction

den Brok, M. H., Nierkens, S., Wagenaars, J. A., Ruers, T. J., Schrier, C. C., Rijke, E. O. & Adema, G. J., 17 Jan 2012, In: Vaccine. 30, 4, p. 737-44 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

2011

Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics

Plantinga, T. S., van Maren, W. W. C., van Bergenhenegouwen, J., Hameetman, M., Nierkens, S., Jacobs, C., de Jong, D. J., Joosten, L. A. B., van't Land, B., Garssen, J., Adema, G. J. & Netea, M. G., Apr 2011, In: Clinical and Vaccine Immunology. 18, 4, p. 621-8 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Harnessing dendritic cells for tumor antigen presentation

Nierkens, S. & Janssen, E. M., 2011, In: Cancers. 3, 2, p. 2195-213 19 p.

Research output: Contribution to journal › Article › Academic › peer-review

Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells

Nierkens, S., den Brok, M. H., Garcia, Z., Togher, S., Wagenaars, J., Wassink, M., Boon, L., Ruers, T. J., Figdor, C. G., Schoenberger, S. P., Adema, G. J. & Janssen, E. M., 2011, In: Cancer Research. 71, 20, p. 6428-37 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation

van Maren, W. W. C., Nierkens, S., Toonen, L. W., Bolscher, J. M., Sutmuller, R. P. M. & Adema, G. J., 2011, In: BMC Immunology [E]. 12, p. 23

Research output: Contribution to journal › Article › Academic › peer-review

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

Lesterhuis, W. J., Punt, C. J. A., Hato, S. V., Eleveld-Trancikova, D., Jansen, B. J. H., Nierkens, S., Schreibelt, G., de Boer, A., Van Herpen, C. M. L., Kaanders, J. H., van Krieken, J. H. J. M., Adema, G. J., Figdor, C. G. & de Vries, I. J. M., Aug 2011, In: Journal of Clinical Investigation. 121, 8, p. 3100-8 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo

Hennies, C. M., Reboulet, R. A., Garcia, Z., Nierkens, S., Wolkers, M. C. & Janssen, E. M., 2011, In: Clinical and Experimental Immunology. 163, 3, p. 381-91 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

2010

Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice

Reboulet, R. A., Hennies, C. M., Garcia, Z., Nierkens, S. & Janssen, E. M., 15 Sept 2010, In: Journal of Immunology. 185, 6, p. 3337-47 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

2009

Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice

Moens, L., Jeurissen, A., Nierkens, S., Boon, L., Van Kaer, L., Kasran, A., Wuyts, G., Ceuppens, J. L. & Bossuyt, X., 2009, In: Infection and Immunity. 77, 5, p. 1976-80 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors

Jacobs, J. F. M., Idema, A. J., Bol, K. F., Nierkens, S., Grauer, O. M., Wesseling, P., Grotenhuis, J. A., Hoogerbrugge, P. M., de Vries, I. J. M. & Adema, G. J., Aug 2009, In: Neuro-Oncology. 11, 4, p. 394-402 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice

Nierkens, S., den Brok, M. H., Roelofsen, T., Wagenaars, J. A. L., Figdor, C. G., Ruers, T. J. & Adema, G. J., 2009, In: PLoS ONE [E]. 4, 12, p. e8368

Research output: Contribution to journal › Article › Academic › peer-review

2008

Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model

Grauer, O. M., Sutmuller, R. P. M., van Maren, W., Jacobs, J. F. M., Bennink, E., Toonen, L. W. J., Nierkens, S. & Adema, G. J., 15 Apr 2008, In: International Journal of Cancer. 122, 8, p. 1794-802 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy

Nierkens, S., den Brok, M. H., Sutmuller, R. P. M., Grauer, O. M., Bennink, E., Morgan, M. E., Figdor, C. G., Ruers, T. J. M. & Adema, G. J., 1 Jul 2008, In: Cancer Research. 68, 13, p. 5390-6 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

TLR ligands in the local treatment of established intracerebral murine gliomas

Grauer, O. M., Molling, J. W., Bennink, E., Toonen, L. W. J., Sutmuller, R. P. M., Nierkens, S. & Adema, G. J., 15 Nov 2008, In: Journal of Immunology. 181, 10, p. 6720-9 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Toll-like receptor signalling on Tregs: to suppress or not to suppress?

van Maren, W. W. C., Jacobs, J. F. M., de Vries, I. J. M., Nierkens, S. & Adema, G. J., Aug 2008, In: Immunology. 124, 4, p. 445-52 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

2007

CD4+CD25+ T cells regulate the intensity of hypersensitivity responses to peanut, but are not decisive in the induction of oral sensitization

van Wijk, F., Wehrens, E. J. M., Nierkens, S., Boon, L., Kasran, A., Pieters, R. & Knippels, L. M. J., Apr 2007, In: Clinical and Experimental Allergy. 37, 4, p. 572-81 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins

van Wijk, F., Nierkens, S., de Jong, W., Wehrens, E. J. M., Boon, L., van Kooten, P., Knippels, L. M. J. & Pieters, R., 1 Jun 2007, In: Journal of Immunology. 178, 11, p. 6894-900 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

2006

Assessment of drug-induced immunotoxicity in animal models

van Wijk, F. & Nierkens, S., 2006, In: Drug discovery today. Technologies. 3, 1, p. 103-9 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity

den Brok, M. H. M. G. M., Sutmuller, R. P. M., Nierkens, S., Bennink, E. J., Frielink, C., Toonen, L. W. J., Boerman, O. C., Figdor, C. G., Ruers, T. J. M. & Adema, G. J., 2006, In: British Journal of Cancer. 95, 7, p. 896-905 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine

den Brok, M. H. M. G. M., Sutmuller, R. P. M., Nierkens, S., Bennink, E. J., Toonen, L. W. J., Figdor, C. G., Ruers, T. J. M. & Adema, G. J., 15 Jul 2006, In: Cancer Research. 66, 14, p. 7285-92 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

The reporter antigen popliteal lymph node assay

Nierkens, S. & Pieters, R., 2006, In: Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]. Chapter 18, p. Unit18.12

Research output: Contribution to journal › Article › Academic › peer-review

2005

Anti-inflammatory and immune regulatory properties of 5-androsten-3beta, 17beta-diol (HE2100), and synthetic analogue HE3204: implications for treatment of autoimmune diseases

Auci, D., Nicoletti, F., Mangano, K., Pieters, R., Nierkens, S., Morgan, L., Offner, H., Frincke, J. & Reading, C., Jun 2005, In: Annals of the New York Academy of Sciences. 1051, p. 730-42 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Dendritic cells: tools and targets for antitumor vaccination

den Brok, M. H. M. G. M., Nierkens, S., Figdor, C. G., Ruers, T. J. M. & Adema, G. J., 2005, In: Expert Review of Vaccines. 4, 5, p. 699-710 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Development of an oral exposure mouse model to predict drug-induced hypersensitivity reactions by using reporter antigens

Nierkens, S., Aalbers, M., Bol, M., van Wijk, F., Hassing, I. & Pieters, R., Feb 2005, In: Toxicological Sciences. 83, 2, p. 273-81 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Center for Translational Immunology (CTI) Lab support

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