Center for Translational Immunology (CTI) Lab support

Research output

Research output per year 2000 2005 2011 2015 2016 2017 2024

• 63 Article
• 7 Meeting Abstract
• 4 Comment/Letter to the editor
• 4 Review article
• 1 More
  • 1 Doctoral thesis 1 (Research UU / Graduation UU)

Research output per year

Research output per year

Search results

• 2024

  A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

  Venema, W. J., Hiddingh, S., van Loosdregt, J., Bowes, J., Balliu, B., de Boer, J. H., Ossewaarde-van Norel, J., Thompson, S. D., Langefeld, C. D., de Ligt, A., van der Veken, L. T., Krijger, P. H. L., de Laat, W. & Kuiper, J. J. W., 10 Jan 2024, In: Cell genomics. 4, 1, 100460.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Lethal 100%
  • Enhancer 99%
  • Autoimmune Diseases 72%
  • Single Nucleotide Polymorphism 70%
  • Genes 33%
  21 Downloads (Pure)

• CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders

  Picavet, L. W., Samat, A. A. K., Calis, J., Nijhuis, L., Scholman, R., Mokry, M., Tough, D. F., Prinjha, R. K., Vastert, S. J. & van Loosdregt, J., 18 Jun 2024, In: Biomedicines. 12, 6, 14 p., 1344.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • CREB-Binding Protein 100%
  • Disorder 58%
  • T-Lymphocytes 42%
  • Juvenile Arthritis 32%
  • Protein 28%

• m⁶A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by Downregulating Membrane CX3CR1 Expression

  Picavet, L. W., van Vroonhoven, E. C. N., Scholman, R. C., Smits, Y. T. H., Banerjee, R., Besteman, S. B., Viveen, M. C., van der Vlist, M. M., Tanenbaum, M. E., Lebbink, R. J., Vastert, S. J. & van Loosdregt, J., May 2024, In: Viruses. 16, 5, 14 p., 778.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • CX3C Chemokine Receptor 1 100%
  • Respiratory Syncytial Virus Infections 77%
  • Respiratory Syncytial Viruses 70%
  • Protein Domains 60%
  • Methylation 43%
  1 Downloads (Pure)
• 2023

  Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis

  Servaas, N. H., Hiddingh, S., Chouri, E., Wichers, C. G. K., Affandi, A. J., Ottria, A., Bekker, C. P. J., Cossu, M., Silva-Cardoso, S. C., van der Kroef, M., Hinrichs, A. C., Carvalheiro, T., Vazirpanah, N., Beretta, L., Rossato, M., Bonte-Mineur, F., Radstake, T. R. D. J., Kuiper, J. J. W., Boes, M. & Pandit, A., Feb 2023, In: Arthritis & Rheumatology. 75, 2, p. 279-292 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Systemic Scleroderma 100%
  • Cytoplasmic and Nuclear Receptors 89%
  • Dendritic Cells 78%
  • Gene Regulatory Networks 59%
  • Chromatin Immunoprecipitation Sequencing 28%
  5 Downloads (Pure)

• Nuclear segmentation facilitates neutrophil migration

  Shen, C., Mulder, E., Buitenwerf, W., Postat, J., Jansen, A., Kox, M., Mandl, J. N. & Vrisekoop, N., 1 Jun 2023, In: Journal of cell science. 136, 11, 7 p., jcs260768.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Confined Spaces 25%
  • Emergency Responders 22%
  • Lab-On-A-Chip Devices 21%
  • Neutrophil Infiltration 18%
  8 Downloads (Pure)

• Retina-arrestin specific CD8+ T cells are not implicated in HLA-A29-positive birdshot chorioretinitis

  Venema, W. J., Hiddingh, S., Janssen, G. M. C., Ossewaarde-van Norel, J., van Loon, N. D., de Boer, J. H., van Veelen, P. A. & Kuiper, J. J. W., Feb 2023, In: Clinical Immunology. 247, p. 1-10 10 p., 109219.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • HLA-A29 antigen 100%
  • Birdshot Chorioretinopathy 94%
  • Arrestin 79%
  • Retina 47%
  • T-Lymphocytes 33%

• Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

  Hiddingh, S., Pandit, A., Verhagen, F. H., Rijken, R., Servaas, N. H., Wichers, C. G. K., Ten Dam-Van Loon, N. H., Imhof, S. M., Radstake, T. R. D. J., de Boer, J. H. & Kuiper, J. J. W., 12 Apr 2023, In: eLife. 12, e74913.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Uveitis 100%
  • Cytometry 92%
  • Gene Expression Profiling 91%
  • Dendritic Cells 79%
  • Interferon Type I 79%
  3 Downloads (Pure)
• 2021

  Signaling by the inhibitory receptor CD200R is rewired by type I interferon

  van der Vlist, M., Pascoal Ramos, M. I., van den Hoogen, L. L., Hiddingh, S., Timmerman, L. M., de Hond, T. A. P., Kaan, E. D., van der Kroef, M., Lebbink, R. J., Peters, F. M. A., Khoury-Hanold, W., Fritsch-Stork, R., Radstake, T. R. D. J. & Meyaard, L., 12 Oct 2021, In: Science Signaling [E]. 14, 704, p. 1-11 eabb4324.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Interferon Type I 100%
  • Systemic Lupus Erythematosus 78%
  • Toll-Like Receptors 45%
  • Interferons 38%
  • p120 GTPase Activating Protein 38%
• 2018

  Classing it up to get noticed: MHC class 1 antigen display in dendritic cells and neuroblastoma

  Spel, L., 8 Feb 2018, Utrecht University. 161 p.

  Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

  Open Access

  File

  • Neuroblastoma 100%
  • Dendritic Cells 89%
  • Antigens 63%
  • T-Lymphocytes 28%
  • Antigen Presentation 25%
  5 Downloads (Pure)
• 2017

  An Ocular Protein Triad Can Classify Four Complex Retinal Diseases

  Kuiper, J. J. W., Beretta, L., Nierkens, S., Van Leeuwen, R., Ten Dam-Van Loon, N. H., Ossewaarde-Van Norel, J., De Groot-Mijnes, J. D. F., Schellekens, P., De Boer, J. H. & Radstake, T. R. D. J., 27 Jan 2017, In: Scientific Reports. 7, 41595.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Eye Proteins 100%
  • Retinal Diseases 71%
  • Ophthalmologists 65%
  • interleukin-21 39%
  • Eye 36%

• Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis

  Admiraal, R., Nierkens, S., de Witte, M. A., Petersen, E. J., Fleurke, G-J., Verrest, L., Belitser, S. V., Bredius, R. G. M., Raymakers, R. A. P., Knibbe, C. A. J., Minnema, M. C., van Kesteren, C., Kuball, J. & Boelens, J. J., Apr 2017, In: Lancet haematology. 4, 4, p. e183–e191

  Research output: Contribution to journal › Article › Academic › peer-review

  • Antilymphocyte Serum 100%
  • Cell Transplantation 85%
  • Cohort Studies 54%
  • Survival 44%
  • Graft vs Host Disease 37%

• EASI p-EASI: Utilizing a combination of serum biomarkers offers an objective measurement tool for disease severity in atopic dermatitis patients

  Thijs, J. L., Drylewicz, J., Fiechter, R., Strickland, I., Sleeman, M. A., Herath, A., May, R. D., Bruijnzeel-Koomen, C. A. F. M., Knol, E. F., Giovannone, B., de Bruin-Weller, M. S., Nierkens, S. & Hijnen, D. J., Dec 2017, In: Journal of Allergy and Clinical Immunology. 140, 6, p. 1703-1705 3 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

• Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences

  Berbers, R-M., Nierkens, S., van Laar, J. M., Bogaert, D. & Leavis, H. L., 1 Mar 2017, In: Trends in immunology. 38, 3, p. 206-216 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Common Variable Immunodeficiency 100%
  • Dysbiosis 89%
  • Microbiota 35%
  • Immune System Diseases 19%
  • Gastrointestinal Microbiome 17%

• Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis

  Thijs, J. L., Strickland, I., Bruijnzeel-Koomen, C. A. F. M., Nierkens, S., Giovannone, B., Csomor, E., Sellman, B. R., Mustelin, T., Sleeman, M. A., de Bruin-Weller, M. S., Herath, A., Drylewicz, J., May, R. D. & Hijnen, D. J., Sept 2017, In: Journal of Allergy and Clinical Immunology. 140, 3, p. 730-737 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Atopic Dermatitis 100%
  • Biomarkers 62%
  • Serum 43%
  • Tissue Inhibitor of Metalloproteinase-1 22%
  • Principal Component Analysis 20%

• Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation

  Admiraal, R., de Koning, C. C. H., Lindemans, C. A., Bierings, M. B., Wensing, A. M. J., Versluys, A. B., Wolfs, T. F. W., Nierkens, S. & Boelens, J. J., Dec 2017, In: Journal of Allergy and Clinical Immunology. 140, 6, p. 1643-1650.e9

  Research output: Contribution to journal › Article › Academic › peer-review

  • Immune Reconstitution 100%
  • Cell Transplantation 81%
  • Adenoviridae 74%
  • BK Virus 63%
  • Human Herpesvirus 6 61%
• 2016

  Antithymocyte globulin: Importance of good clinical pharmacological practice

  Admiraal, R., van Kesteren, C., Nierkens, S. & Boelens, J. J., Aug 2016, In: Journal of Allergy and Clinical Immunology. 138, 2, p. 633

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

• Excellent T-cell reconstitution and survival provided ATG exposure is low or absent after pediatric cord blood transplantation

  Admiraal, R., Lindemans, C. A., van Kesteren, C., Bierings, M. B., Versluijs, A. B., Nierkens, S. & Boelens, J. J., 2016, In: Blood. 128, 23, p. 2734-2741

  Research output: Contribution to journal › Article › Academic › peer-review

  • Antilymphocyte Serum 100%
  • Cord 98%
  • Immune Reconstitution 93%
  • Fetal Blood 78%
  • Transplantation 60%

• Immune Reconstitution after Allogeneic Hematopoietic Cell Transplantation in Children

  de Koning, C., Plantinga, M., Besseling, P., Boelens, J. J. & Nierkens, S., Feb 2016, In: Biology of Blood and Marrow Transplantation. 22, 2, p. 195-206 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Immune Reconstitution 100%
  • Cell Transplantation 81%
  • Allogeneic Cells 81%
  • Child 32%
  • Chemokines 17%
  1 Citation (Scopus)

  1 Downloads (Pure)

• Leukemia-free survival in myeloid leukemia, but not in lymphoid leukemia, is predicted by early CD4+ reconstitution following unrelated cord blood transplantation in children: a multicenter retrospective cohort analysis

  Admiraal, R., Chiesa, R., Lindemans, C. A., Nierkens, S., Bierings, M. B., Versluijs, A. B., Hiwarkar, P., Furtado Silva, J. M., Veys, P. & Boelens, J. J., 2016, In: Bone Marrow Transplantation. 51, 10, p. 1376-1378 3 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

• Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses.

  Seyfizadeh, N., Muthuswamy, R., Mitchell, D., Nierkens, S. & Seyfizadeh, N., Nov 2016, In: Critical Reviews in Oncology Hematology. 107, p. 100-110

  Research output: Contribution to journal › Article › Academic › peer-review

  • Dendritic Cells 100%
  • Lymph Nodes 79%
  • Immunotherapy 39%
  • Neoplasms 36%
  • Cancer Vaccines 27%

• Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

  van Montfrans, J. M., Hartman, E. A. R., Braun, K. P. J., Hennekam, E. A. M., Hak, E. A., Nederkoorn, P. J., Westendorp, W. F., Bredius, R. G. M., Kollen, W. J. W., Schölvinck, E. H., Elizabeth Legger, G., Meyts, I., Liston, A., Lichtenbelt, K. D., Giltay, J. C., Van Haaften, G., De Vries Simons, G. M., Leavis, H., Sanders, C. J. G., Bierings, M. B., & 2 othersNierkens, S. & Van Gijn, M. E., 1 May 2016, In: Rheumatology (Oxford, England). 55, 5, p. 902-910 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Severe combined immunodeficiency due to adenosine deaminase deficiency 100%
  • Population Biological Variation 78%
  • Adenosine Deaminase 53%
  • Mutation 35%
  • Cell Transplantation 15%

• Strategies before, during, and after hematopoietic cell transplantation to improve T-cell immune-reconstitution

  de Koning, C., Nierkens, S. & Boelens, J. J., 2016, In: Blood. 128, 23, p. 2607-2615

  Research output: Contribution to journal › Article › Academic › peer-review

  • Immune Reconstitution 100%
  • Adjuvant 93%
  • Cell Transplantation 81%
  • T-Lymphocytes 46%
  • Allogeneic Cells 40%

• Systemic Inflammatory Immune Signatures in a Patient with CRB1 linked Retinal Dystrophy

  Verhagen, F., Kuiper, J., Nierkens, S., Imhof, S. M., Radstake, T. & de Boer, J., 2016, In: Expert Review of Clinical Immunology. 12, 12, p. 1359-1362

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Retinal Dystrophies 100%
  • Intermediate Uveitis 73%
  • Immunosuppressive Agents 38%
  • interleukin-21 32%
  • interleukin-22 31%
  1 Downloads (Pure)

• The magnitude of cytokine production by stimulated CD56+ cells is associated with early stages of systemic sclerosis

  Cossu, M., van Bon, L., Nierkens, S., Bellocchi, C., Santaniello, A., Dolstra, H., Beretta, L. & Radstake, TRDJ., Dec 2016, In: Clinical Immunology. 173, p. 76-80

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Systemic Scleroderma 100%
  • Cytokines 54%
  • Raynaud Disease 49%
  • Natural Killer T-Cells 11%
  • Innate Immunity 8%
• 2015

  Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children

  Janssen, W. J. M., Nierkens, S., Sanders, E. A., Boes, M. & van Montfrans, J. M., 17 Nov 2015, In: Vaccine. 33, 46, p. 6320-6326 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • 23-valent pneumococcal capsular polysaccharide vaccine 100%
  • deficiency diseases 90%
  • Deficiency Diseases 87%
  • Pneumococcal Vaccines 78%
  • Immunoglobulin A 58%

• Challenges in the harmonization of immune monitoring studies and trial design for cell-based therapies in the context of hematopoietic cell transplantation for pediatric cancer patients

  Nierkens, S., Lankester, A. C., Egeler, R. M., Bader, P., Locatelli, F., Pulsipher, M. A., Bollard, C. M. & Boelens, J. J., 1 Dec 2015, In: Cytotherapy. 17, 12, p. 1667-1674 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Immunologic Monitoring 100%
  • Cell Transplantation 83%
  • Cell- and Tissue-Based Therapy 73%
  • Clinical Trials 50%
  • Pediatrics 49%

• Cognate CD4 T-Cell Licensing of Dendritic Cells Heralds Anti-Cytomegalovirus CD8 T-Cell Immunity after Human Allogeneic Umbilical Cord Blood Transplantation

  Flinsenberg, T. W. H., Spel, L., Jansen, M., Koning, D., de Haar, C., Plantinga, M., Scholman, R., van Loenen, M. M., Nierkens, S., Boon, L., van Baarle, D., Heemskerk, M. H. M., Boelens, J. J. & Boes, M., 15 Jan 2015, In: Journal of Virology. 89, 2, p. 1058-1069 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cytomegalovirus 100%
  • umbilical cord 96%
  • dendritic cells 94%
  • Licensure 77%
  • Fetal Blood 70%

• Correlation between measurement of IL-10 and IL-6 in paired aqueous humour and vitreous fluid in primary vitreoretinal lymphoma

  Kuiper, J., ten Dam-van Loon, N., Domanian, A., Schellekens, P., Nierkens, S., Radstake, T. & de Boer, J., Dec 2015, In: Acta Ophthalmologica. 93, 8, p. e680–e681

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
  12 Citations (Scopus)

• Generation of a cord blood-derived Wilms Tumor 1 dendritic cell vaccine for AML patients treated with allogeneic cord blood transplantation

  de Haar, C., Plantinga, M., Blokland, N. J. G., van Til, N. P., Flinsenberg, T. W. H., Van Tendeloo, V. F., Smits, E. L., Boon, L., Spel, L., Boes, M., Boelens, J. J. & Nierkens, S., Nov 2015, In: OncoImmunology. 4, 11, p. e1023973 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Wilms Tumor 100%
  • Fetal Blood 82%
  • Acute Myeloid Leukemia 79%
  • Dendritic Cells 74%
  • Cell Transplantation 71%

• Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

  Spel, L., Boelens, J. J., Van Der Steen, D. M., Blokland, N. J. G., van Noesel, M. M., Molenaar, J. J., Heemskerk, M. H. M., Boes, M. & Nierkens, S., 2015, In: Oncotarget. 6, 34, p. 35770-35781 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neuroblastoma 100%
  • Natural Killer Cells 93%
  • T-Lymphocytes 61%
  • Cytotoxic T-Lymphocytes 33%
  • Immunotherapy 13%

• Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

  Van Montfrans, J., Hartman, E., Braun, K., Hennekam, F., Hak, A., Nederkoorn, P., Westendorp, W., Bredius, R., Kollen, W., Scholvinck, E., Legger, G., Meyts, I., Liston, A., Lichtenbelt, K., Giltay, J., Van Haaften, G., De Vries Simons, G., Leavis, H., Nierkens, S., Sanders, C., & 1 othersVan Gijn, M., 28 Sept 2015, In: Pediatric Rheumatology. 13, 1, O7.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Preclinical Development of Cord Blood-Derived Dendritic Cell-Based Immunotherapies after Hematopoietic Cell Transplantation in Children with AML

  de Haar, C., Plantinga, M., Blokland, N., Dunnebach, E., Boes, M., Boelens, J. & Nierkens, S., Feb 2015, In: Biology of Blood and Marrow Transplantation. 21, 2, p. S192-S193 2 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• PRECLINICAL DEVELOPMENT OF CORD BLOOD-DERIVED DENDRITIC CELL-BASED IMMUNOTHERAPIES AFTER HEMATOPOIETIC CELL TRANSPLANTATION IN CHILDREN WITH AML

  Haar, C. D., Plantinga, M., Blokland, N., Dunnebach, E., Til, N. V., Boes, M., Boelens, J. J. & Nierkens, S., Jun 2015, In: Cytotherapy. 17, 6, p. S9-S9 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity

  Nierkens, S., Spel, L., van der Steen, D., Blokland, N., Heemskerk, M., Boelens, J. & Boes, M., Feb 2015, In: Biology of Blood and Marrow Transplantation. 21, 2, p. S240-S240 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

  • Cytotoxic T-Lymphocytes 100%
  • Neuroblastoma 92%
  • Natural Killer Cells 86%
  • Up-Regulation 66%
  • Dendritic Cells 20%

• UPREGULATION OF CLASS I MHC ON NEUROBLASTOMA CELLS BY NK CELL EXPOSURE FOR ENHANCED CTL REACTIVITY

  Spel, L., van der Steen, D., Blokland, N., van Noesel, M., Heemskerk, M., Boelens, J. J., Boes, M. & Nierkens, S., Jun 2015, In: Cytotherapy. 17, 6, p. S19-S19 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Will Post-Transplantation Cell Therapies for Pediatric Patients Become Standard of Care?

  Lankester, A. C., Locatelli, F., Bader, P., Rettinger, E., Egeler, M., Katewa, S., Pulsipher, M. A., Nierkens, S., Schultz, K., Handgretinger, R., Grupp, S. A., Boelens, J. J. & Bollard, C. M., Mar 2015, In: Biology of Blood and Marrow Transplantation. 21, 3, p. 402-411 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Hematopoietic Stem Cell Transplantation 100%
  • Graft vs Host Disease 98%
  • Standard of Care 90%
  • Cell- and Tissue-Based Therapy 88%
  • Transplantation 71%
• 2014

  Antigen-Specific IGA Titers After 23-Valent Pneumococcal Vaccine Differentiate Transient from Persistent Antibody Deficiency Disease

  Janssen, W. J. M., Nierkens, S., Boes, M. & van Montfrans, J. M., Oct 2014, In: Journal of Clinical Immunology. 34, p. S409-S409 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma

  Kroesen, M., Nierkens, S., Ansems, M., Wassink, M., Orentas, R. J., Boon, L., den Brok, M. H., Hoogerbrugge, P. M. & Adema, G. J., 2014, In: International Journal of Cancer. 134, 6, p. 1335-45 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Neuroblastoma 100%
  • Neoplasms 32%
  • Immunotherapy 17%
  • sialogangliosides 15%
  • Monoclonal Antibodies 14%

• Development of a Unique Anti-AML Immune Therapy Consisting of Cord Blood HSCT and Cord Blood Stem Cell-Derived Dendritic Cell (CB-DC) Vaccination

  de Haar, C., Plantinga, M., Blokland, N., Spel, L., Boes, M., Nierkens, S. & Boelens, J-J., Feb 2014, In: Biology of Blood and Marrow Transplantation. 20, 2, p. S133-S133 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2013

  Antitumor immune responses mediated by dendritic cells: How signals derived from dying cancer cells drive antigen cross-presentation

  Spel, L., Boelens, J-J., Nierkens, S. & Boes, M., 1 Nov 2013, In: OncoImmunology. 2, 11, 10 p., 26403.

  Research output: Contribution to journal › Review article › peer-review

  • Cross-Priming 100%
  • Antigen Presentation 77%
  • Dendritic Cells 63%
  • Antigens 44%
  • Adaptive Immunity 36%

• AUTOMATED HEMATOLOGY ANALYZERS FAIL TO DETECT LYMPHOCYTE VACUOLIZATION IN INBORN ERRORS OF METABOLISM

  Oostendorp, M., van Hasselt, P. M., Nierkens, S. & Huisman, A., May 2013, In: International Journal of Laboratory Hematology. 35, p. 59-59 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2012

  Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

  Jacobs, J. F. M., Nierkens, S., Figdor, C. G., de Vries, I. J. M. & Adema, G. J., Jan 2012, In: LANCET ONCOLOGY. 13, 1, p. e32-42

  Research output: Contribution to journal › Article › Academic › peer-review

  • Regulatory T-Lymphocytes 100%
  • Immunotherapy 88%
  • Melanoma 83%
  • Tumor Microenvironment 62%
  • Tumor Escape 53%

• Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined with in situ tumor destruction

  den Brok, M. H., Nierkens, S., Wagenaars, J. A., Ruers, T. J., Schrier, C. C., Rijke, E. O. & Adema, G. J., 17 Jan 2012, In: Vaccine. 30, 4, p. 737-44 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • cancer vaccines 100%
  • Cancer Vaccines 65%
  • Saponins 63%
  • immunity 60%
  • adjuvants 56%
• 2011

  Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics

  Plantinga, T. S., van Maren, W. W. C., van Bergenhenegouwen, J., Hameetman, M., Nierkens, S., Jacobs, C., de Jong, D. J., Joosten, L. A. B., van't Land, B., Garssen, J., Adema, G. J. & Netea, M. G., Apr 2011, In: Clinical and Vaccine Immunology. 18, 4, p. 621-8 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Bifidobacterium breve 100%
  • Lactobacillus 69%
  • Toll-Like Receptors 66%
  • Probiotics 64%
  • Lactobacillus rhamnosus 42%

• Harnessing dendritic cells for tumor antigen presentation

  Nierkens, S. & Janssen, E. M., 2011, In: Cancers. 3, 2, p. 2195-213 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Antigen Presentation 100%
  • Neoplasm Antigens 97%
  • Dendritic Cells 82%
  • T-Lymphocytes 56%
  • Antigen-Presenting Cells 48%

• Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells

  Nierkens, S., den Brok, M. H., Garcia, Z., Togher, S., Wagenaars, J., Wassink, M., Boon, L., Ruers, T. J., Figdor, C. G., Schoenberger, S. P., Adema, G. J. & Janssen, E. M., 2011, In: Cancer Research. 71, 20, p. 6428-37 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Oligonucleotides 100%
  • Dendritic Cells 86%
  • Neoplasm Antigens 40%
  • Immunity 31%
  • Neoplasms 30%

• Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation

  van Maren, W. W. C., Nierkens, S., Toonen, L. W., Bolscher, J. M., Sutmuller, R. P. M. & Adema, G. J., 2011, In: BMC Immunology [E]. 12, p. 23

  Research output: Contribution to journal › Article › Academic › peer-review

  • Eragrostis 100%
  • Legionella 79%
  • Toll-Like Receptor 2 76%
  • Ligands 42%
  • T-Lymphocytes 37%

• Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

  Lesterhuis, W. J., Punt, C. J. A., Hato, S. V., Eleveld-Trancikova, D., Jansen, B. J. H., Nierkens, S., Schreibelt, G., de Boer, A., Van Herpen, C. M. L., Kaanders, J. H., van Krieken, J. H. J. M., Adema, G. J., Figdor, C. G. & de Vries, I. J. M., Aug 2011, In: Journal of Clinical Investigation. 121, 8, p. 3100-8 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Platinum 100%
  • Death Domain Receptors 58%
  • Pharmaceutical Preparations 39%
  • Ligands 33%
  • Neoplasms 30%

• Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo

  Hennies, C. M., Reboulet, R. A., Garcia, Z., Nierkens, S., Wolkers, M. C. & Janssen, E. M., 2011, In: Clinical and Experimental Immunology. 163, 3, p. 381-91 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • flt3 ligand protein 100%
  • Dendritic Cells 59%
  • Cancer Vaccines 30%
  • Neoplasms 21%
  • Antigens 21%
• 2010

  Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice

  Reboulet, R. A., Hennies, C. M., Garcia, Z., Nierkens, S. & Janssen, E. M., 15 Sept 2010, In: Journal of Immunology. 185, 6, p. 3337-47 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Dendritic Cells 100%
  • Antigens 70%
  • T-Lymphocytes 50%
  • Neoplasms 36%
  • Psychology Transfer 11%