Center for Molecular Medicine

Research output

Research output per year 1988 1997 1998 2002 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 2792 Article
• 222 Doctoral thesis 1 (Research UU / Graduation UU)
• 134 Review article
• 74 Doctoral thesis 2 (Research NOT UU / Graduation UU)
• 280 More
  • 62 Meeting Abstract
  • 58 Chapter
  • 58 Comment/Letter to the editor
  • 22 Poster
  • 18 Letter
  • 16 Abstract
  • 11 Editorial
  • 7 Paper
  • 4 Book
  • 4 Literature review
  • 4 Short survey
  • 4 Preprint
  • 3 Web publication/site
  • 2 Other contribution
  • 2 Patent
  • 1 Report
  • 1 Inaugural speech
  • 1 Conference contribution
  • 1 Foreword/postscript
  • 1 Doctoral thesis 3 (Research UU / Graduation NOT UU)

Research output per year

Research output per year

Search results

• 2024

  FOXO transcription factors as mediators of stress adaptation

  Rodriguez-Colman, M. J., Dansen, T. B. & Burgering, B. M. T., Jan 2024, In: Nature reviews molecular cell biology. 25, 1, p. 46-64 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • Longevity 100%
  • Transcription Factors 83%
  • Caenorhabditis elegans 81%
  • Homeostasis 54%
  • Insulin Receptor 41%

• Human liver organoids: From generation to applications

  Afonso, M. B., Marques, V., van Mil, S. W. C. & Rodrigues, C. M. P., 1 Jun 2024, In: Hepatology (Baltimore, Md.). 79, 6, p. 1432-1451 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Organoids 100%
  • Liver 39%
  • Liver Diseases 21%
  • Bioengineering 16%
  • Pluripotent Stem Cells 14%
  1 Downloads (Pure)

• Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice

  Samsom, K. G., Bosch, L. J. W., Schipper, L. J., Schout, D., Roepman, P., Boelens, M. C., Lalezari, F., Klompenhouwer, E. G., de Langen, A. J., Buffart, T. E., van Linder, B. M. H., van Deventer, K., van den Burg, K., Unmehopa, U., Rosenberg, E. H., Koster, R., Hogervorst, F. B. L., van den Berg, J. G., Riethorst, I., Schoenmaker, L., & 9 othersvan Beek, D., de Bruijn, E., van der Hoeven, J. J. M., van Snellenberg, H., van der Kolk, L. E., Cuppen, E., Voest, E. E., Meijer, G. A. & Monkhorst, K., Mar 2024, In: Nature protocols. 19, 3, p. 700-726 27 p.

  Research output: Contribution to journal › Review article › peer-review

  • Whole Genome Sequencing 100%
  • Workflow 94%
  • Biological Marker 77%
  • Pathology 54%
  • Neoplasms 27%

• The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

  Sleeboom, J. J. F., van Tienderen, G. S., Schenke-Layland, K., van der Laan, L. J. W., Khalil, A. A. & Verstegen, M. M. A., 3 Jan 2024, In: Science translational medicine. 16, 728, 3840.

  Research output: Contribution to journal › Review article › peer-review

  • Biomechanical Phenomena 100%
  • Extracellular Matrix 88%
  • Neoplasm Metastasis 64%
  • Neoplasms 33%
  • Therapeutics 17%

• Vertebrate centromere architecture: from chromatin threads to functional structures

  Andrade Ruiz, L., Kops, G. J. P. L. & Sacristan, C., Jul 2024, In: Chromosoma. 133, 3, p. 169-181 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Centromere 100%
  • Vertebrates 73%
  • Chromatin 72%
  • Centromere Protein B 24%
  • condensin complexes 21%

• Whole genome sequencing in (recurrent) glioblastoma: challenges related to informed consent procedures and data sharing

  Hasner, M. C., van Opijnen, M. P., de Vos, F. Y. F., Cuppen, E. & Broekman, M. L. D., 14 Jun 2024, In: Acta Neurochirurgica. 166, 1, 8 p., 266.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Information Dissemination 100%
  • Whole Genome Sequencing 98%
  • Glioblastoma 83%
  • Informed Consent 82%
  • Population 16%
  1 Downloads (Pure)
• 2023

  Advanced omics techniques shed light on CD1d-mediated lipid antigen presentation to iNKT cells

  Morris, I., Croes, C-A., Boes, M. & Kalkhoven, E., May 2023, In: Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1868, 5, 159292.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Natural Killer T-Cells 100%
  • Antigen Presentation 91%
  • Lipids 54%
  • CD1d Antigen 27%
  • Antigen-Presenting Cells 17%

• Modeling specific aneuploidies: from karyotype manipulations to biological insights

  Truong, M. A., Cané-Gasull, P. & Lens, S. M. A., 29 Aug 2023, In: Chromosome Research. 31, 3, 27 p., 25.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Aneuploidy 100%
  • Karyotype 94%
  • Cell Physiological Phenomena 29%
  • Neoplasms 22%
  • Chromosomes 18%

• Permission to pass: on the role of p53 as a gatekeeper for aneuploidy

  Marques, J. F. & Kops, G. J. P. L., Dec 2023, In: Chromosome Research. 31, 4, 23 p., 31.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Aneuploidy 100%
  • Neoplasms 18%
  • Chromosomes 18%
  • Genome 15%
  • Haploidy 14%
  9 Downloads (Pure)

• Poor handling of continuous predictors in clinical prediction models using logistic regression: a systematic review

  Ma, J., Dhiman, P., Qi, C., Bullock, G., van Smeden, M., Riley, R. D. & Collins, G. S., Sept 2023, In: Journal of Clinical Epidemiology. 161, p. 140-151 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Systematic Reviews 100%
  • Logistic Models 88%
  • PubMed 35%
  • Research Personnel 31%
  3 Downloads (Pure)

• Principles and dynamics of spindle assembly checkpoint signalling

  McAinsh, A. D. & Kops, G. J. P. L., Aug 2023, In: Nature reviews molecular cell biology. 24, 8, p. 543-559 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • M Phase Cell Cycle Checkpoints 100%
  • Kinetochores 27%
  • Anaphase 27%
  • Microtubules 20%
  • Chromosomes 16%

• Targeting the myeloid microenvironment in neuroblastoma

  Stip, M. C., Teeuwen, L., Dierselhuis, M. P., Leusen, J. H. W. & Krijgsman, D., 13 Dec 2023, In: Journal of Experimental and Clinical Cancer Research. 42, 1, 26 p., 337.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Myeloid Cells 100%
  • Neuroblastoma 97%
  • Immunotherapy 18%
  • Immunosuppressive Agents 17%
  • Tumor Microenvironment 14%
  15 Downloads (Pure)

• The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease

  Tsioumpekou, M., Krijgsman, D., Leusen, J. H. W. & Olofsen, P. A., Aug 2023, In: Cells. 12, 15, 24 p., 1981.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Plastic Property 100%
  • White 72%
  • Neutrophils 67%
  • Block Like Crystal 58%
  • Cytokines 53%
  11 Downloads (Pure)

• The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures

  Balážová, K., Clevers, H. & Dost, A. F. M., Feb 2023, In: eLife. 12, e82998.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Immunomodulating Agent 100%
  • Coculture Techniques 56%
  • Non-Small Cell Lung Carcinoma 51%
  • Macrophages 40%
  • Organoids 28%
  13 Downloads (Pure)
• 2022

  A kaleidoscopic view of extracellular vesicles in lysosomal storage disorders

  Hegeman, C. V., de Jong, O. G. & Lorenowicz, M. J., 2022, In: Extracellular Vesicles and Circulating Nucleic Acids. 3, 4, p. 393-421 29 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • lysosomal proteins 15%
  • Lipids 13%
  • Enzyme Replacement Therapy 13%
  • Gene Editing 12%

• Analytical demands to use whole-genome sequencing in precision oncology

  Meggendorfer, M., Jobanputra, V., Wrzeszczynski, K. O., Roepman, P., de Bruijn, E., Cuppen, E., Buttner, R., Caldas, C., Grimmond, S., Mullighan, C. G., Elemento, O., Rosenquist, R., Schuh, A. & Haferlach, T., Sept 2022, In: Seminars in Cancer Biology. 84, p. 16-22 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Whole Genome Sequencing 100%
  • Gene Library 13%
  • Clinical Decision-Making 12%
  • Cytogenetics 12%
  • Computational Biology 11%
  15 Downloads (Pure)

• Biomarkers for Cyclin-Dependent Kinase 4/6 Inhibitors in the Treatment of Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced/Metastatic Breast Cancer: Translation to Clinical Practice

  Bui, T. B. V., Burgering, B. M. T., Goga, A., Rugo, H. S. & Van 'T Veer, L. J., 1 Jun 2022, In: JCO Precision Oncology. 6, 1, p. 1-17 e2100473.

  Research output: Contribution to journal › Review article › peer-review

  • Cyclin-Dependent Kinase 6 100%
  • Cyclin-Dependent Kinase 4 91%
  • human ERBB2 protein 79%
  • Hormones 45%
  • Biomarkers 42%

• Changing places: Chromosomal Passenger Complex relocation in early anaphase

  Hadders, M. A. & Lens, S. M. A., Feb 2022, In: Trends in Cell Biology. 32, 2, p. 165-176 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Anaphase 100%
  • Centromere 62%
  • Microtubules 50%
  • Cell Nucleus Division 37%
  • CDC2 Protein Kinase 37%

• Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

  Klaasen, S. J. & Kops, G. J. P. L., Nov 2022, In: Cells. 11, 22, 3564.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Meiosis 100%
  • Aneuploidy 92%
  • Mitosis 85%
  • Chromosome Segregation 71%
  • Chromosomes 68%
  4 Downloads (Pure)

• Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology

  Jobanputra, V., Wrzeszczynski, K. O., Buttner, R., Caldas, C., Cuppen, E., Grimmond, S., Haferlach, T., Mullighan, C., Schuh, A. & Elemento, O., Sept 2022, In: Seminars in Cancer Biology. 84, p. 23-31 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Whole Exome Sequencing 100%
  • Whole Genome Sequencing 97%
  • Genome 57%
  • Gene Fusion 31%
  • Point Mutation 27%

• Clinical utility of whole-genome sequencing in precision oncology

  Rosenquist, R., Cuppen, E., Buettner, R., Caldas, C., Dreau, H., Elemento, O., Frederix, G., Grimmond, S., Haferlach, T., Jobanputra, V., Meggendorfer, M., Mullighan, C. G., Wordsworth, S. & Schuh, A., Sept 2022, In: Seminars in Cancer Biology. 84, p. 32-39 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Whole Genome Sequencing 100%
  • Clinical Trials 42%
  • Genome 29%
  • Neoplasms 27%
  • Drug Approval 27%
  11 Citations (Scopus)

• Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting

  Aristin Revilla, S., Kranenburg, O. & Coffer, P. J., 8 Jul 2022, In: Frontiers in Immunology. 13, 903564.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Regulatory T-Lymphocytes 100%
  • Colorectal Neoplasms 80%
  • Tumor Microenvironment 57%
  • Neoplasms 26%
  • Therapeutics 16%

• Diffuse gastric cancer: Emerging mechanisms of tumor initiation and progression

  Monster, J. L., Kemp, L. J. S., Gloerich, M. & van der Post, R. S., May 2022, In: Biochimica et Biophysica Acta-Reviews on Cancer. 1877, 3, 188719.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Stomach Neoplasms 100%
  • Neoplasms 37%
  • Organoids 16%
  • Tumor Microenvironment 13%
  • Drug Therapy 7%

• FOXOs: masters of the equilibrium

  Gui, T. & Burgering, B. M. T., Dec 2022, In: FEBS Journal. 289, 24, p. 7918-7939 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Longevity 100%
  • Mutation 94%
  • Genomic Instability 91%
  • Pharmacological Metabolism 86%
  • Forkhead Transcription Factors 73%
  1 Citation (Scopus)

• Gut Microbiota in Colorectal Cancer: Associations, Mechanisms, and Clinical Approaches

  Pleguezuelos-Manzano, C., Puschhof, J. & Clevers, H., Apr 2022, In: Annual Review of Cancer Biology. 6, p. 65-84 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Gastrointestinal Microbiome 100%
  • Colorectal Neoplasms 80%
  • Microbiota 33%
  • Fusobacterium nucleatum 23%
  • Bacteria 22%
  10 Downloads (Pure)

• Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care

  Cuppen, E., Elemento, O., Rosenquist, R., Nikic, S., IJzerman, M., Zaleski, I. D., Frederix, G., Levin, L-Å., Mullighan, C. G., Buettner, R., Pugh, T. J., Grimmond, S., Caldas, C., Andre, F., Custers, I., Campo, E., van Snellenberg, H., Schuh, A., Nakagawa, H., von Kalle, C., & 3 othersHaferlach, T., Fröhling, S. & Jobanputra, V., Dec 2022, In: JCO Precision Oncology. 6, e2200245.

  Research output: Contribution to journal › Review article › peer-review

  • Whole Exome Sequencing 100%
  • Whole Genome Sequencing 97%
  • Neoplasms 27%
  • Costs and Cost Analysis 19%
  • Delivery of Health Care 19%

• Mechanical forces directing intestinal form and function

  Houtekamer, R. M., van der Net, M. C., Maurice, M. M. & Gloerich, M., 25 Jul 2022, In: Current Biology. 32, 14, p. R791-R805

  Research output: Contribution to journal › Review article › peer-review

  • Intestines 100%
  • Force 74%
  • intestines 73%
  • Homeostasis 40%
  • homeostasis 37%

• Multiplex Tissue Imaging: Spatial Revelations in the Tumor Microenvironment

  van Dam, S., Baars, M. J. D. & Vercoulen, Y., 28 Jun 2022, In: Cancers. 14, 13, p. 1-30 3170.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Tumor Microenvironment 100%
  • Neoplasms 31%
  • Technology 20%
  • Spatial Navigation 20%
  • Spatial Analysis 20%
  7 Downloads (Pure)

• The cellular composition and function of the bone marrow niche after allogeneic hematopoietic cell transplantation

  Peci, F., Dekker, L., Pagliaro, A., van Boxtel, R., Nierkens, S. & Belderbos, M., Sept 2022, In: Bone Marrow Transplantation. 57, 9, p. 1357-1364 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cell Transplantation 100%
  • Allogeneic Cells 99%
  • Bone Marrow 67%
  • Transplantation Conditioning 37%
  • Hematopoietic Stem Cells 34%
  7 Downloads (Pure)

• The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer

  Wölfl, B., te Rietmole, H., Salvioli, M., Kaznatcheev, A., Thuijsman, F., Brown, J. S., Burgering, B. & Staňková, K., Jun 2022, In: Dynamic Games and Applications. 12, 2, p. 313-342 30 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Evolutionary Game Theory 100%
  • Cancer 77%
  • Game theory 72%
  • Game-theoretic Models 37%
  • Evolutionary Game 31%
  2 Citations (Scopus)

  7 Downloads (Pure)
• 2021

  3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation

  van den Brink, S. C. & van Oudenaarden, A., Sept 2021, In: Trends in Cell Biology. 31, 9, p. 747-759 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Gastrula 100%
  • Gastrulation 92%
  • Embryonic Stem Cells 75%
  • Embryonic Development 65%
  • Embryonic Structures 58%

• A Systematic Review with Meta-Analysis of the Efficacy of Cannabis and Cannabinoids for Inflammatory Bowel Disease: What Can We Learn from Randomized and Nonrandomized Studies?

  Doeve, B. H., Van De Meeberg, M. M., Van Schaik, F. D. M. & Fidder, H. H., 1 Oct 2021, In: Journal of Clinical Gastroenterology. 55, 9, p. 798-809 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cannabinoids 100%
  • Cannabis 91%
  • Inflammatory Bowel Diseases 81%
  • Meta-Analysis 64%
  • Systematic Reviews 63%
  4 Citations (Scopus)

• Breast milk nutrients driving intestinal epithelial layer maturation via Wnt and Notch signaling: Implications for necrotizing enterocolitis

  de Jong, J. C. W., Ijssennagger, N. & van Mil, S. W. C., 1 Nov 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 11, p. 1-9 166229.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Necrotizing Enterocolitis 100%
  • Human Milk 89%
  • Nutrients 69%
  • Epithelial Cells 29%
  • Cell Lineage 28%
  7 Downloads (Pure)

• Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

  ETH Zurich, 6 May 2021, In: Cell stem cell. 28, 5, p. 816-832 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Organoids 100%
  • Terminology 76%
  • Liver 39%
  • Benchmarking 16%
  • Regeneration 12%
  21 Citations (Scopus)

• Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

  Oct 2021, In: Journal of Hepatology. 75, 4, p. 770-785 16 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Elasticity Imaging Techniques 100%
  • Non-alcoholic Fatty Liver Disease 88%
  • Meta-Analysis 61%
  • Systematic Reviews 60%
  • Magnetic Resonance Imaging 54%
  2 Citations (Scopus)

  3 Downloads (Pure)

• Early technology assessment of using whole genome sequencing in personalized oncology

  Simons, M., van de Ven, M., Coupé, V., Joore, M., IJzerman, M., Koffijberg, E., Frederix, G., Uyl-De Groot, C., Cuppen, E., van Harten, W. & Retèl, V., Jun 2021, In: Expert Review of Pharmacoeconomics and Outcomes Research. 21, 3, p. 343-351 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Biomedical Technology Assessment 100%
  • technology assessment 93%
  • Whole Genome Sequencing 91%
  • diagnostic 66%
  • Clinical Practice 48%
  7 Downloads (Pure)

• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

  Jan 2021, In: Autophagy. 17, 1, p. 1-382 382 p.

  Research output: Contribution to journal › Review article › peer-review

  • Autophagy 100%
  • Guidelines 66%
  • Knowledge Bases 11%
  • Eukaryota 9%
  • Evaluation Studies 8%

• Mutations and mechanisms of WNT pathway tumour suppressors in cancer

  Bugter, J. M., Fenderico, N. & Maurice, M. M., Jan 2021, In: Nature Reviews Cancer. 21, 1, p. 5-21 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Mutation 100%
  • Catenins 64%
  • Neoplasms 57%
  • Adult Stem Cells 29%
  • Loss of Function Mutation 28%

• Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture

  Tjalsma, S. J. & de Laat, W., Apr 2021, In: Current Opinion in Genetics & Development. 67, p. 10-17 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Genome 100%
  • Chromosomes 58%
  • Technology 24%
  • Population 14%
  15 Downloads (Pure)

• Organoid-based modeling of intestinal development, regeneration, and repair

  Sprangers, J., Zaalberg, I. C. & Maurice, M. M., Jan 2021, In: Cell Death and Differentiation. 28, 1, p. 95-107 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Organoids 100%
  • Wnt Signaling Pathway 86%
  • Intestinal Mucosa 80%
  • Regeneration 63%
  • Epithelial Cells 54%
  5 Citations (Scopus)

  18 Downloads (Pure)

• Post-Translational Modifications of FXR; Implications for Cholestasis and Obesity-Related Disorders

  Appelman, M. D., van der Veen, S. W. & van Mil, S. W. C., 27 Sept 2021, In: Frontiers in Endocrinology. 12, p. 1-13 729828.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cholestasis 100%
  • Bile Acids and Salts 91%
  • Post Translational Protein Processing 90%
  • Obesity 61%
  • Dietary Fats 21%

• PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action

  Hernandez-Quiles, M., Broekema, M. F. & Kalkhoven, E., 26 Feb 2021, In: Frontiers in Endocrinology. 12, 624112.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Peroxisome Proliferator-Activated Receptors 100%
  • PPAR gamma 91%
  • Immunity 67%
  • Neoplasms 26%
  • Loss of Function Mutation 15%
  14 Citations (Scopus)

  15 Downloads (Pure)

• Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies

  Weijts, B., Yvernogeau, L. & Robin, C., 24 Nov 2021, In: Frontiers in Immunology. 12, 790379.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Diving 100%
  • Hematopoiesis 82%
  • Hematopoietic Stem Cells 74%
  • Technology 49%
  • Mesonephros 47%

• The eha research roadmap: normal hematopoiesis

  Jaffredo, T., Balduini, A., Bigas, A., Bernardi, R., Bonnet, D., Canque, B., Charbord, P., Cumano, A., Delwel, R., Durand, C., Fibbe, W., Forrester, L., De Franceschi, L., Ghevaert, C., Gjertsen, B., Gottgens, B., Graf, T., Heidenreich, O., Hermine, O., Higgs, D., & 21 othersKleanthous, M., Klump, H., Kouskoff, V., Krause, D., Lacaud, G., Lo Celso, C., Martens, J. H. A., Méndez-Ferrer, S., Menendez, P., Oostendorp, R., Philipsen, S., Porse, B., Raaijmakers, M., Robin, C., Stunnenberg, H., Theilgaard-Mönch, K., Touw, I., Vainchenker, W., Corrons, J. L. V., Yvernogeau, L. & Schuringa, J. J., 30 Dec 2021, In: HemaSphere. 5, 12, p. 1-9 e669.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Hematopoiesis 100%
  • Hematology 98%
  • Blood Coagulation Disorders 14%
  • Hemostatic Disorders 12%
  • Transfusion Medicine 11%
  10 Downloads (Pure)

• The frontier of live tissue imaging across space and time

  Huang, Q., Garrett, A., Bose, S., Blocker, S., Rios, A. C., Clevers, H. & Shen, X., 1 Apr 2021, In: Cell stem cell. 28, 4, p. 603-622 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cell Self Renewal 100%
  • Regeneration 67%
  • Homeostasis 58%

• The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks

  Kendek, A., Wensveen, M. R. & Janssen, A., Sept 2021, In: Genes. 12, 9, 1415.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Chromatin 100%
  • DNA Repair 52%
  • DNA Damage 49%
  • DNA Breaks 34%
  • DNA 31%
  1 Downloads (Pure)
• 2020

  Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants

  Post, J. B., Roodhart, J. M. L. & Snippert, H. J. G., Feb 2020, In: Trends in Cancer. 6, 2, p. 111-129 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • Organoids 100%
  • Colorectal Neoplasms 60%
  • Gene Editing 23%
  • Oncogenes 18%
  • Protein Isoforms 15%

• CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

  Hendriks, D., Clevers, H. & Artegiani, B., 5 Nov 2020, In: Cell stem cell. 27, 5, p. 705-731 27 p.

  Research output: Contribution to journal › Review article › peer-review

  • Organoids 100%
  • Genetic Engineering 95%
  • Clustered Regularly Interspaced Short Palindromic Repeats 87%
  • Stem Cells 56%
  • CRISPR-Cas Systems 30%

• Eleven grand challenges in single-cell data science

  7 Feb 2020, In: Genome Biology. 21, 1, p. 1-35 31.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Data Science 100%
  • science 46%
  • cell (biology) 36%
  • microfluidic technology 29%
  • Microfluidics 28%
  10 Downloads (Pure)

• Emerging insights on the role of gasdermins in infection and inflammatory diseases

  Tang, L., Lu, C., Zheng, G. & Burgering, B. M. T., Oct 2020, In: Clinical & Translational Immunology. 9, 10, p. 1-18 e1186.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Pyroptosis 100%
  • Porins 98%
  • Infections 72%
  • Innate Immunity 69%
  • Autoimmune Diseases 65%
  4 Downloads (Pure)