Center for Molecular Medicine

Research output

Research output per year 1988 1997 1998 2002 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 2795 Article
• 223 Doctoral thesis 1 (Research UU / Graduation UU)
• 134 Review article
• 74 Doctoral thesis 2 (Research NOT UU / Graduation UU)
• 282 More
  • 62 Meeting Abstract
  • 58 Chapter
  • 58 Comment/Letter to the editor
  • 22 Poster
  • 20 Letter
  • 16 Abstract
  • 11 Editorial
  • 7 Paper
  • 4 Book
  • 4 Literature review
  • 4 Short survey
  • 4 Preprint
  • 3 Web publication/site
  • 2 Other contribution
  • 2 Patent
  • 1 Report
  • 1 Inaugural speech
  • 1 Conference contribution
  • 1 Foreword/postscript
  • 1 Doctoral thesis 3 (Research UU / Graduation NOT UU)

Research output per year

Research output per year

Search results

• 2024

  Glioblastoma, IDH-wildtype with primarily leptomeningeal localization diagnosed by nanopore sequencing of cell-free DNA from cerebrospinal fluid

  Sol, N., Kooi, E. J., Pagès-Gallego, M., Brandsma, D., Bugiani, M., de Ridder, J., Wesseling, P. & Vermeulen, C., 3 Sept 2024, In: Acta Neuropathologica. 148, 1, p. 1-4 4 p., 35.

  Research output: Contribution to journal › Letter › Academic › peer-review

  Open Access

  File
• 2023

  Recommending revised hepatoblastoma surveillance in children with a pathogenic ARID1A variant. Reply to “Cancer in ARID1A-Coffin-Siris syndrome: Review and report of a child with hepatoblastoma” by Cárcamo et al. 2022

  van der Sluijs, P. J., Vergano, S. A., Roeder, E. R., Jongmans, M. C. J. & Santen, G. W. E., Feb 2023, In: European Journal of Medical Genetics. 66, 2, 104694.

  Research output: Contribution to journal › Letter › Academic › peer-review
• 2021

  A public–private partnership model for COVID-19 diagnostics

  Krijger, P. H. L., Hoek, T. A., Boersma, S., Donders, L. I. P. M., Broeders, M. M. C., Pieterse, M., Toonen, P. W., Logister, I., Verhagen, B. M. P., Verstegen, M. J. A. M., van Ravesteyn, T. W., Roymans, R. J. T. M., Mattiroli, F., Vandesompele, J., Nijhuis, M., Meijer, S., van Weert, A., Dekker, E., Dom, F. J., Ruijtenbeek, R., & 5 othersvan der Velden, L. B. J., van de Bovenkamp, J. H. B., Bosch, M., de Laat, W. & Tanenbaum, M. E., Oct 2021, In: Nature Biotechnology. 39, 10, p. 1182-1184 3 p.

  Research output: Contribution to journal › Letter › Academic › peer-review
• 2019

  Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

  Logtenberg, M. E. W., Jansen, J. H. M., Raaben, M., Toebes, M., Franke, K., Brandsma, A. M., Matlung, H. L., Fauster, A., Gomez-Eerland, R., Bakker, N. A. M., van der Schot, S., Marijt, K. A., Verdoes, M., Haanen, J. B. A. G., van den Berg, J. H., Neefjes, J., van den Berg, T. K., Brummelkamp, T. R., Leusen, J. H. W., Scheeren, F. A., & 1 othersSchumacher, T. N., Apr 2019, In: Nature Medicine. 25, 4, p. 612-619 8 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • glutaminyl-peptide cyclotransferase 100%
  • Immunotherapy 46%
  • Effector 28%
  • Cell Death 27%
  • Biosynthesis 21%
• 2017

  Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

  Yost, S., De Wolf, B., Hanks, S., Zachariou, A., Marcozzi, C., Clarke, M., de Voer, R. M., Etemad, B., Uijttewaal, E., Ramsay, E., Wylie, H., Elliott, A., Picton, S., Smith, A., Smithson, S. F., Seal, S., Ruark, E., Houge, G., Pines, J., Kops, G. J. P. L., & 1 othersRahman, N., 1 Jul 2017, In: Nature Genetics. 49, 7, p. 1148-1151 4 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • M Phase Cell Cycle Checkpoints 100%
  • Wilms Tumor 88%
  • Aneuploidy 59%
  • Chromosomes 58%
  • Mutation 41%

• Interplay between metabolic identities in the intestinal crypt supports stem cell function

  Rodríguez-Colman, M. J., Schewe, M., Meerlo, M., Stigter, E., Gerrits, J., Pras-Raves, M., Sacchetti, A., Hornsveld, M., Oost, K. C., Snippert, H. J., Verhoeven-Duif, N., Fodde, R. & Burgering, B. M. T., 2017, In: Nature. 543, 7645, p. 424-427 4 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Paneth Cells 100%
  • Stem Cells 50%
  • Oxidative Phosphorylation 25%
  • Reactive Oxygen Species 18%
  • Homeostasis 16%

• Reply: Poor Sensitivity and Specificity of Electrocardiographic Estimation of Myocardial Mass

  van der Harst, P. & de Bakker, P. I. W., 28 Feb 2017, In: Journal of the American College of Cardiology. 69, 8, p. 1099-1099 1 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  Open Access

• Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

  Van den Brink, S. C., Sage, F., Vértesy, Á., Spanjaard, B., Peterson-Maduro, J., Baron, C. S., Robin, C. & Van Oudenaarden, A., 1 Oct 2017, In: Nature Methods. 14, p. 935-936 2 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

• Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

  Janda, C. Y., Dang, L. T., You, C., Chang, J., Lau, W. D., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, DI., Li, X., Moody, J. D., Williams, B. O., Clevers, H., Piehler, J., Baker, D., Kuo, C. J. & Garcia, K. C., 11 May 2017, In: Nature. 545, 7653, p. 234-237 4 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Wnt Proteins 100%
  • Catenins 87%
  • Frizzled Receptors 53%
  • Wnt Receptors 17%
  • Lipoylation 16%
• 2016

  A reference panel of 64,976 haplotypes for genotype imputation

  McCarthy, S., Das, S., Kretzschmar, W., Delaneau, O., Wood, A. R., Teumer, A., Kang, H. M., Fuchsberger, C., Danecek, P., Sharp, K., Luo, Y., Sidore, C., Kwong, A., Timpson, N., Koskinen, S., Vrieze, S., Scott, L. J., Zhang, H., Mahajan, A., Veldink, J., & 30 othersPeters, U., Pato, C., van Duijn, C. M., Gillies, C. E., Gandin, I., Mezzavilla, M., Gilly, A., Cocca, M., Traglia, M., Angius, A., Barrett, J. C., Boomsma, D., Branham, K., Breen, G., Brummett, C. M., Busonero, F., Campbell, H., Chan, A., Chen, S., Chew, E., Collins, F. S., Corbin, L. J., Smith, G. D., Dedoussis, G., Dorr, M., Farmaki, A-E., Van den Berg, L. H., Van Rheenen, W., de Bakker, P. I. W. & Dekker, A., 22 Aug 2016, In: Nature Genetics. 48, p. 1279–1283

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Haplotypes 100%
  • Single Nucleotide Polymorphism 89%
  • Genotype 76%
  • Gene Frequency 51%
  • Research Personnel 37%

• Designer matrices for intestinal stem cell and organoid culture

  Gjorevski, N., Sachs, N., Manfrin, A., Giger, S., Bragina, M. E., Ordóñez-Morán, P., Clevers, H. & Lutolf, M. P., 24 Nov 2016, In: Nature. 539, 7630, p. 560-564 5 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Organoids 100%
  • Cell Culture Techniques 58%
  • Stem Cells 56%
  • Extracellular Matrix 16%
  • Laminin 10%
  11 Citations (Scopus)

• Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

  van Rheenen, W., Shatunov, A., Dekker, A. M., McLaughlin, R. L., Diekstra, F. P., Pulit, S. L., van der Spek, R. A. A., Võsa, U., de Jong, S., Robinson, M. R., Yang, J., Fogh, I., van Doormaal, P. T., Tazelaar, G. H. P., Koppers, M., Blokhuis, A. M., Sproviero, W., Jones, A. R., Kenna, K. P., van Eijk, K. R., & 30 othersHarschnitz, O., Schellevis, R. D., Brands, W. J., Medic, J., Menelaou, A., Vajda, A., Ticozzi, N., Lin, K., Rogelj, B., Vrabec, K., Ravnik-Glavač, M., Koritnik, B., Zidar, J., Leonardis, L., Grošelj, L. D., Millecamps, S., Salachas, F., Meininger, V., de Carvalho, M., Pinto, S., Mora, J. S., Rojas-García, R., Polak, M., Ophoff, R. A., Blauw, H. M., de Bakker, P. I. W., van Es, M. A., Pasterkamp, R. J., van den Berg, L. H. & Veldink, J. H., Sept 2016, In: Nature Genetics. 48, 9, p. 1043–1048

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Genome-Wide Association Study 97%
  • Genome 25%
  • Chromosomes, Human, Pair 21 24%
  • Multifactorial Inheritance 22%

• Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

  Farin, H. F., Jordens, I., Mosa, M. H., Basak, O., Korving, J., Tauriello, D. V. F., De Punder, K., Angers, S., Peters, P. J., Maurice, M. M. & Clevers, H., 18 Feb 2016, In: Nature. 530, 7590, p. 340-343 4 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Stem Cell Niche 100%
  • Frizzled Receptors 59%
  • Stem Cells 57%
  • Wnt Proteins 55%
  • Cell Membrane 42%
  5 Citations (Scopus)
• 2015

  Genome-wide patterns and properties of de novo mutations in humans

  Francioli, L. C., Polak, P. P., Koren, A., Menelaou, A., Chun, S., Renkens, I. J., Van Duijn, C. M., Swertz, M., Wijmenga, C., Van Ommen, G., Slagboom, P. E., Boomsma, D. I., Ye, K., Guryev, V., Arndt, P. F., Kloosterman, W. P., De Bakker, P. I. W. & Sunyaev, S. R., 26 Jun 2015, In: Nature Genetics. 47, 7, p. 822-826 5 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Mutation Rate 100%
  • Genome 80%
  • Mutation 66%
  • Medical Genetics 31%
  • Pan troglodytes 29%
  6 Citations (Scopus)

• Regulation of endoplasmic reticulum turnover by selective autophagy

  Khaminets, A., Heinrich, T., Mari, M., Grumati, P., Huebner, A. K., Akutsu, M., Liebmann, L., Stolz, A., Nietzsche, S., Koch, N., Mauthe, M., Katona, I., Qualmann, B., Weis, J., Reggiori, F., Kurth, I., Hübner, C. A. & Dikic, I., 18 Jun 2015, In: Nature. 522, 7556, p. 354-8 5 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Autophagy 100%
  • Endoplasmic Reticulum 99%
  • human RETREG1 protein 22%
  • Proteins 12%
  • Homeostasis 12%

• Single-cell messenger RNA sequencing reveals rare intestinal cell types

  Grün, D., Lyubimova, A., Kester, L., Wiebrands, K., Basak, O., Sasaki, N., Clevers, H. & van Oudenaarden, A., 10 Sept 2015, In: Nature. 525, 7568, p. 251-255 5 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • RNA Sequence Analysis 100%
  • Messenger RNA 50%
  • Organoids 20%
  • Stem Cells 15%
  • Population 10%

• What is an adult stem cell? Tissues may use diverse mechanisms to replace lost cells

  Clevers, H., 11 Dec 2015, In: Science. 350, 6266, p. 1319-1320 2 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

• Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

  Lenz, T. L., Deutsch, A. J., Han, B., Hu, X., Okada, Y., Eyre, S., Knapp, M., Zhernakova, A., Huizinga, T. W. J., Abecasis, G., Becker, J., Boeckxstaens, G. E., Chen, W-M., Franke, A., Gladman, D. D., Gockel, I., Gutierrez-Achury, J., Martin, J., Nair, R. P., Nöthen, M. M., & 17 othersOnengut-Gumuscu, S., Rahman, P., Rantapää-Dahlqvist, S., Stuart, P. E., Tsoi, L. C., van Heel, D. A., Worthington, J., Wouters, M. M., Klareskog, L., Elder, J. T., Gregersen, P. K., Schumacher, J., Rich, S. S., Wijmenga, C., Sunyaev, S. R., de Bakker, P. I. W. & Raychaudhuri, S., Sept 2015, In: Nature Genetics. 47, 9, p. 1085-1090 6 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Celiac Disease 100%
  • HLA Antigens 93%
  • Autoimmune Diseases 78%
  • Rheumatoid Arthritis 74%
  • Psoriasis 44%
• 2006

  Snelle prenatale diagnostiek van chromosomale afwijkingen; beperkingen en mogelijkheden

  Translated title of the contribution: Rapid prenatal diagnosis of chromosomal abnormalities; limitations and possibilities [3]Boormans, E. M. A., Van Lith, J. M. M., Bilardo, C. M., Knegt, A. C., Oepkes, D., Hoffer, M. J. V., Boon, E. M. J., Wildschut, H. I. J., Galjaard, R. J. H., Schuring-Blom, G. H., Van Oppen, A. C. C., Smits, A., Creemers, J., Go, A., Nieuwint, A., Nijhuis, J. G., De Die, C., Bonsel, G. J., Birnie, E. & Leschot, N. J., 4 Nov 2006, In: Nederlands Tijdschrift voor Geneeskunde. 150, 44, 1 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  1 Citation (Scopus)
• 1995

  Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  Burgering, B. M. T. & Coffer, P. J., 17 Aug 1995, In: Nature. 376, 6541, p. 599-602 4 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  • Proto-Oncogene Proteins c-akt 100%
  • Phosphatidylinositol 3-Kinases 83%
  • Signal Transduction 65%
  • Phosphotransferases 21%
  • gag Gene Products 12%
  1799 Citations (Scopus)